LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

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Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Ito K et al. Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. 2001 J. Biol. Chem. pmid:11500505
Iliás A et al. Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). 2002 J. Biol. Chem. pmid:11880368
Campbell JD et al. Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1). 2004 J. Biol. Chem. pmid:14561746
Zhao Q and Chang XB Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1. 2004 J. Biol. Chem. pmid:15355964
Furumoto Y et al. The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. 2004 J. Biol. Chem. pmid:15355979
Morii E and Oboki K MITF is necessary for generation of prostaglandin D2 in mouse mast cells. 2004 J. Biol. Chem. pmid:15375155
Loe DW et al. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. 1996 J. Biol. Chem. pmid:8621643
Gao M et al. Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells. 1996 J. Biol. Chem. pmid:8910374
Haimeur A et al. Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity. 2002 J. Biol. Chem. pmid:12186871
Zhang DW et al. Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. 2002 J. Biol. Chem. pmid:11925441
Maekawa A et al. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. 2002 J. Biol. Chem. pmid:11932261
Ahamed J and Ali H Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. 2002 J. Biol. Chem. pmid:11934880
Saino H et al. The catalytic architecture of leukotriene C4 synthase with two arginine residues. 2011 J. Biol. Chem. pmid:21454538
Yang R et al. ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport. 2003 J. Biol. Chem. pmid:12783859
Muñoz NM et al. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. 2003 J. Biol. Chem. pmid:12796497
Zhang DW et al. Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. 2003 J. Biol. Chem. pmid:12954620
Niegowski D et al. Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism. 2014 J. Biol. Chem. pmid:24366866
Yamane Y et al. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. 1998 J. Biol. Chem. pmid:9813007
Carter BZ et al. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. 1998 J. Biol. Chem. pmid:9774450
Hipfner DR et al. Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. 1999 J. Biol. Chem. pmid:10336431
Bukiya AN et al. Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. 2014 J. Biol. Chem. pmid:25371198
Gao M et al. Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1. 2000 J. Biol. Chem. pmid:10777615
Li L et al. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. 1998 J. Biol. Chem. pmid:9632674
Bates ME et al. ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. 2000 J. Biol. Chem. pmid:10753897
Alswied A and Parekh AB Ca2+ Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors. 2015 J. Biol. Chem. pmid:26468289
Cole SP Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. 2014 J. Biol. Chem. pmid:25281745
Bowers RC et al. A novel glutathione containing eicosanoid (FOG7) chemotactic for human granulocytes. 2000 J. Biol. Chem. pmid:10924496
Bakos E et al. Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. 1998 J. Biol. Chem. pmid:9822694
Hong JT et al. Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. 1995 J. Biochem. Toxicol. pmid:8847705
Ren XQ et al. A functional role of intracellular loops of human multidrug resistance protein 1. 2006 J. Biochem. pmid:16861249
Falcón-Pérez JM et al. Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains. 2001 J. Bacteriol. pmid:11466279
De Castro CM et al. Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. 1995 J. Appl. Physiol. pmid:8567572
Hevko JM and Murphy RC Electrospray ionization and tandem mass spectrometry of cysteinyl eicosanoids: leukotriene C4 and FOG7. 2001 J. Am. Soc. Mass Spectrom. pmid:11444597
Devakumar A et al. Structural analysis of leukotriene C4 isomers using collisional activation and 157 nm photodissociation. 2008 J. Am. Soc. Mass Spectrom. pmid:18024058
De Servi S et al. Transcardiac release of leukotriene C4 by neutrophils in patients with coronary artery disease. 1991 J. Am. Coll. Cardiol. pmid:2007712
Olynych TJ et al. Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. 2006 J. Allergy Clin. Immunol. pmid:17030235
Nakasato H et al. Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. 1999 J. Allergy Clin. Immunol. pmid:10482831
Sachs-Olsen C et al. Eoxins: a new inflammatory pathway in childhood asthma. 2010 J. Allergy Clin. Immunol. pmid:20920774
Akin C et al. Mast cell activation syndrome: Proposed diagnostic criteria. 2010 J. Allergy Clin. Immunol. pmid:21035176
Thivierge M et al. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. 2006 J. Allergy Clin. Immunol. pmid:16675346
Zaitsu M et al. A novel pharmacologic action of glucocorticosteroids on leukotriene C4 catabolism. 2001 J. Allergy Clin. Immunol. pmid:11447392
Lee TH et al. Leukotriene E4: perspective on the forgotten mediator. 2009 J. Allergy Clin. Immunol. pmid:19482346
Austen KF et al. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. 2009 J. Allergy Clin. Immunol. pmid:19647860
Chen YH et al. IFN-alpha inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release. 2003 J. Allergy Clin. Immunol. pmid:14610485
Horsmanheimo L et al. Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions. 1996 J. Allergy Clin. Immunol. pmid:8757218
de Paulis A et al. Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. 1996 J. Allergy Clin. Immunol. pmid:8765829
Macglashan DW and Saini SS Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation. 2013 J. Allergy Clin. Immunol. pmid:23791510
Kowalski ML et al. Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. 2003 J. Allergy Clin. Immunol. pmid:13679808
Juergens UR et al. Inhibition of monocyte leukotriene B4 production after aspirin desensitization. 1995 J. Allergy Clin. Immunol. pmid:7636051
Zweiman B et al. Nasal airway changes assessed by acoustic rhinometry and mediator release during immediate and late reactions to allergen challenge. 1997 J. Allergy Clin. Immunol. pmid:9389292