LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

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Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Nunoya K et al. Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). 2003 Drug Metab. Dispos. pmid:12867490
Söderström M et al. Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes. 2003 Biochem. Biophys. Res. Commun. pmid:12878209
Shimizu T et al. Effects of n-3 polyunsaturated fatty acids on indomethacin-induced changes in eicosanoid production and blood flow in the gastric mucosa of rats. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12878448
Zaitsu M et al. Dexamethasone accelerates catabolism of leukotriene C4 in bronchial epithelial cells. 2003 Eur. Respir. J. pmid:12882448
Payen LF et al. Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1). 2003 J. Biol. Chem. pmid:12882957
Lam BK Leukotriene C(4) synthase. 2003 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12895593
Bandeira-Melo C and Weller PF Eosinophils and cysteinyl leukotrienes. 2003 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12895596
Meliton AY et al. Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. 2003 J. Allergy Clin. Immunol. pmid:12897749
Skarzynski DJ et al. Roles of tumor necrosis factor-alpha of the estrous cycle in cattle: an in vivo study. 2003 Biol. Reprod. pmid:12904309
Chen X et al. [Preventive effects of montelukast on hypoxic pulmonary hypertension in rats]. 2003 Sichuan Da Xue Xue Bao Yi Xue Ban pmid:12910720
Lie WJ et al. Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. 2003 Clin. Exp. Allergy pmid:12911788
Moloney ED et al. Release of inflammatory mediators from eosinophils following a hyperosmolar stimulus. 2003 Respir Med pmid:12924520
Zhang DW et al. Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. 2003 Biochemistry pmid:12924948
Zhang DW et al. Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. 2003 J. Biol. Chem. pmid:12954620
Arumugam TV et al. Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. 2003 Br. J. Pharmacol. pmid:12967936
Kowalski ML et al. Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. 2003 J. Allergy Clin. Immunol. pmid:13679808
Agarwal R et al. Glutathione S-transferase-dependent conjugation of leukotriene A4-methyl ester to leukotriene C4-methyl ester in mammalian skin. 1992 Biochem. Pharmacol. pmid:1449522
Zhu X et al. Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. 2003 Life Sci. pmid:14519449
Myou S et al. Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. 2003 J. Immunol. pmid:14530366
Deng YM et al. Coincidental increase of leukotriene B4 between cerebral cortex and lung tissue of sensitized rats. 2003 Acta Pharmacol. Sin. pmid:14531949
Gentile DA et al. Elevations of local leukotriene C4 levels during viral upper respiratory tract infections. 2003 Ann. Allergy Asthma Immunol. pmid:14533659
Campbell JD et al. Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1). 2004 J. Biol. Chem. pmid:14561746
Krasnowska M and Medrala W [Effect of IFN-gamma on IGE dependent leukotriene generation by peripheral blood leukocytes in patients with chronic allergic rhinitis in vitro]. 2003 Pneumonol Alergol Pol pmid:14587429
Shon YH and Nam KS Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. 2003 Phytother Res pmid:14595579
Chen YH et al. IFN-alpha inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release. 2003 J. Allergy Clin. Immunol. pmid:14610485
González J et al. Role of leukotrienes B4 and C4 in liver allograft rejection. 1992 Transpl. Int. pmid:14621902
Westlake CJ et al. Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3. 2003 Biochemistry pmid:14640677
Takala RS et al. Pulmonary inflammatory mediators after sevoflurane and thiopentone anaesthesia in pigs. 2004 Acta Anaesthesiol Scand pmid:14674972
Genovese A et al. Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. 2003 Int. Arch. Allergy Immunol. pmid:14707465
Mitsunobu F et al. Influence of long-term cigarette smoking on immunoglobulin E-mediated allergy, pulmonary function, and high-resolution computed tomography lung densitometry in elderly patients with asthma. 2004 Clin. Exp. Allergy pmid:14720263
Mayatepek E et al. Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. 2004 J. Lipid Res. pmid:14754911
Satake Y et al. Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. 2004 J. Biol. Chem. pmid:14761945
Ito R et al. [Effect of pranlukast on histamine release and leukotriene c4 (ltc4) generation from human peripheral basophils]. 2004 Arerugi pmid:14762327
Koike K et al. Mapping of the MRPm5 epitope to the cytosolic region between transmembrane helices 13 and 14 in the drug and organic anion transporter, MRP1 (ABCC1). 2004 Biochem. Biophys. Res. Commun. pmid:14975760
Woolhiser MR et al. Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. 2004 Clin. Immunol. pmid:15003814
Díaz AM et al. Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. 2004 Life Sci. pmid:15010262
Karimi K et al. Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. 2004 Eur. J. Pharmacol. pmid:15063154
Dimova-Yaneva D et al. Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis. 2004 Clin. Exp. Allergy pmid:15080807
Mandal AK et al. The membrane organization of leukotriene synthesis. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15084748
Findlay VJ et al. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. 2004 Mol. Pharmacol. pmid:15102935
Chang WC and Parekh AB Close functional coupling between Ca2+ release-activated Ca2+ channels, arachidonic acid release, and leukotriene C4 secretion. 2004 J. Biol. Chem. pmid:15133023
Hirano T et al. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. 2004 Int. Arch. Allergy Immunol. pmid:15153793
Ren XQ et al. Function of the ABC signature sequences in the human multidrug resistance protein 1. 2004 Mol. Pharmacol. pmid:15155846
Hirouchi M et al. Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2. 2004 Pharm. Res. pmid:15180328
Situ D et al. Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. 2004 J. Biol. Chem. pmid:15208328
Piette V et al. Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens. 2004 Allergy pmid:15230820
Mayatepek E et al. Acute metabolic crisis with extreme deficiency of glutathione in combination with decreased levels of leukotriene C4 in a patient with glutathione synthetase deficiency. 2004 J. Inherit. Metab. Dis. pmid:15243994
Rigato I et al. The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin. 2004 Biochem. J. pmid:15245331
Trompier D et al. Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1. 2004 Cancer Res. pmid:15256468
Ko JK et al. Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis. 2004 World J. Gastroenterol. pmid:15300893
Hamilton RG and Franklin Adkinson N In vitro assays for the diagnosis of IgE-mediated disorders. 2004 J. Allergy Clin. Immunol. pmid:15316492
Randolph GJ et al. Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. 2005 Springer Semin. Immunopathol. pmid:15338191
Zhao Q and Chang XB Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1. 2004 J. Biol. Chem. pmid:15355964
Furumoto Y et al. The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. 2004 J. Biol. Chem. pmid:15355979
Tarnay JN et al. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. 2004 Insect Mol. Biol. pmid:15373810
Morii E and Oboki K MITF is necessary for generation of prostaglandin D2 in mouse mast cells. 2004 J. Biol. Chem. pmid:15375155
Sharma R et al. RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. 2004 Int. J. Cancer pmid:15386349
Chen J et al. Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model. 2005 Cancer Chemother. Pharmacol. pmid:15455178
Westlake CJ et al. Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. 2004 J. Biol. Chem. pmid:15459206
Ramires R et al. Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast. 2004 Biochem. Biophys. Res. Commun. pmid:15474500
Ninomiya M et al. Functional analysis of dog multidrug resistance-associated protein 2 (Mrp2) in comparison with rat Mrp2. 2005 Drug Metab. Dispos. pmid:15507541
Chen ZS et al. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). 2005 Mol. Pharmacol. pmid:15537867
Hui Y et al. Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure. 2004 Circulation pmid:15545522
Kowalski ML et al. Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine. 2005 Allergy pmid:15575935
Lai YL and Lin TY Mast cells in citric acid-induced cough of guinea pigs. 2005 Toxicol. Appl. Pharmacol. pmid:15589973
Karwatsky J et al. The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. 2005 Biochemistry pmid:15628876
Conseil G et al. Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas. 2005 Biochem. Pharmacol. pmid:15652236
John AE et al. Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. 2005 Am. J. Pathol. pmid:15681819
Payen L et al. Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1). 2005 Mol. Pharmacol. pmid:15755910
Reims A et al. Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. 2005 Scand. J. Gastroenterol. pmid:15764146
Cruse G et al. Activation of human lung mast cells by monomeric immunoglobulin E. 2005 Eur. Respir. J. pmid:15863643
Ito K et al. Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression system. 2005 Life Sci. pmid:15904671
Oskeritzian CA et al. Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. 2005 J. Allergy Clin. Immunol. pmid:15940129
Nunomura S et al. Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. 2005 Int. Immunol. pmid:15944196
Vieira-de-Abreu A et al. Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils. 2005 Am. J. Respir. Cell Mol. Biol. pmid:15947420
Rossi MI et al. Long-term exacerbation by interleukin 13 of IgE-mediated eosinophilia in rats. 2005 Int. Immunopharmacol. pmid:15953562
Hilberg T et al. Transcription in response to physical stress--clues to the molecular mechanisms of exercise-induced asthma. 2005 FASEB J. pmid:16027142
Mortaz E et al. Mast cell activation is differentially affected by heat shock. 2005 Exp. Hematol. pmid:16038788
Lin CH and Lai YL Mast cell mediators in citric acid-induced airway constriction of guinea pigs. 2005 Toxicol. Appl. Pharmacol. pmid:16039945
Rossi A et al. Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}. 2005 J. Leukoc. Biol. pmid:16046553
Yao PL et al. Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. 2005 Respir. Res. pmid:16083514
Noguchi T et al. MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (beta-D-glucuronate). 2005 Biochem. Pharmacol. pmid:16098482
Cao D et al. Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion. 2006 J. Nutr. Biochem. pmid:16098734
Wu P et al. Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites. 2005 Mol. Pharmacol. pmid:16105987
Tkachenko MM et al. [Age-related characteristics of contractile vascular reactions and the content of oxygen free radicals and nitric oxide metabolites in BALB/c mice in conditions of alienation zone]. 2005 Fiziol Zh pmid:16108223
Vilariño N et al. Acute IL-3 priming up-regulates the stimulus-induced Raf-1-Mek-Erk cascade independently of IL-3-induced activation of Erk. 2005 J. Immunol. pmid:16116188
Seres I et al. Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia. 2005 Metab. Clin. Exp. pmid:16125525
Ichiyama T et al. Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. 2005 Clin. Exp. Allergy pmid:16164450
Shilling AD et al. Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. 2006 May-Jun J Pharmacol Toxicol Methods pmid:16176877
Perng DW et al. Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. 2006 Am. J. Respir. Cell Mol. Biol. pmid:16179583
Abad MJ et al. Anti-inflammatory activity of four Bolivian Baccharis species (Compositae). 2006 J Ethnopharmacol pmid:16202549
Niide O et al. Fungal metabolite gliotoxin blocks mast cell activation by a calcium- and superoxide-dependent mechanism: implications for immunosuppressive activities. 2006 Clin. Immunol. pmid:16213796
Raghavenra H et al. Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16216483
Conseil G et al. Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1). 2006 J. Biol. Chem. pmid:16230346
Kulka M and Metcalfe DD TLR3 activation inhibits human mast cell attachment to fibronectin and vitronectin. 2006 Mol. Immunol. pmid:16280166
Zaitsu M et al. Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16280246
Mayatepek E et al. A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. 2005 Ann. Neurol. pmid:16315285
Son JK et al. Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. 2005 Biol. Pharm. Bull. pmid:16327145
Feng C et al. Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses. 2006 Blood pmid:16357326
Liu S et al. Activation of connective tissue-type and mucosal-type mast cells in compound 48/80-induced airway response. 2006 Eur. J. Pharmacol. pmid:16360144