LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

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Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Kalayci O et al. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. 2006 Allergy pmid:16364163
Zhang DW et al. Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): effect on substrate specificity. 2006 Drug Metab. Dispos. pmid:16415113
Mesquita-Santos FP et al. Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. 2006 J. Immunol. pmid:16424158
Trandafir CC et al. Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. 2005 Clin. Exp. Pharmacol. Physiol. pmid:16445567
Jordan TR et al. An approach of immunoneurological aspects in nasal allergic late phase. 2005 Sep-Oct Allergy Asthma Proc pmid:16450573
Wijewickrama GT et al. Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells. 2006 J. Biol. Chem. pmid:16476735
Jordan TR et al. [Clinical symptoms and mediators in the allergic early and late phase reaction]. 2006 Laryngorhinootologie pmid:16498540
Dahlén SE Treatment of asthma with antileukotrienes: first line or last resort therapy? 2006 Eur. J. Pharmacol. pmid:16510137
Snyder DW et al. Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips. 1991 Eur. J. Pharmacol. pmid:1651863
Li GQ et al. Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation. 2006 J. Infect. Dis. pmid:16518767
Chavez J et al. Interactions between leukotriene C4 and interleukin 13 signaling pathways in a mouse model of airway disease. 2006 Arch. Pathol. Lab. Med. pmid:16594735
Uzonyi B et al. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16606835
Kramer MF et al. Factors contributing to nasal allergic late phase eosinophilia. 2006 May-Jun Am J Otolaryngol pmid:16647984
Thivierge M et al. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. 2006 J. Allergy Clin. Immunol. pmid:16675346
Son MJ et al. Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. 2006 Arch. Pharm. Res. pmid:16681032
Choi YH et al. Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. 2006 Arch. Pharm. Res. pmid:16681034
Ra C [IGE-FCepsilonRI-mast cell paradigm in allergy]. 2006 Arerugi pmid:16718997
Davoine F et al. Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis. 2006 Int. Arch. Allergy Immunol. pmid:16735797
Hua Z et al. Evaluation and interference of serum and skin lesion levels of leukotrienes in patients with eczema. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16757158
Muñoz NM et al. Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. 2006 J. Immunol. pmid:16785555
Tschopp CM et al. Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. 2006 Blood pmid:16794249
Deng JM and Shi HZ Interleukin-16 in asthma. 2006 Chin. Med. J. pmid:16805986
Engin A et al. Regulation of fibrogenesis during the early phase of common bile duct obstruction. 2006 ANZ J Surg pmid:16813633
Ren XQ et al. A functional role of intracellular loops of human multidrug resistance protein 1. 2006 J. Biochem. pmid:16861249
Medrala W et al. [Efficacy and safety of specific immunotherapy of upper airways allergic diseases caused by allergy to mites]. 2006 Pol. Merkur. Lekarski pmid:16875150
Capra V et al. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. 2007 Med Res Rev pmid:16894531
Wang XS and Lau HY Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16895550
Abe M et al. A novel method for preserving human lungs using a super-cooling system. 2006 Ann. Thorac. Surg. pmid:16928543
Hoopes C Invited commentary. 2006 Ann. Thorac. Surg. pmid:16928544
Ninomiya M et al. Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (Mrp2). 2006 Drug Metab. Dispos. pmid:16936067
Serio KJ et al. TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16980379
Ciana P et al. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. 2006 EMBO J. pmid:16990797
Chang WC et al. Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c-fos through ERK-dependent and -independent pathways in mast cells. 2006 FASEB J. pmid:17023391
Olynych TJ et al. Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. 2006 J. Allergy Clin. Immunol. pmid:17030235
Gulliksson M et al. Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. 2006 Allergy pmid:17073880
Zaitsu M et al. Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. 2007 Mol. Immunol. pmid:17084457
Chen X et al. Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention. 2006 Curr Cancer Drug Targets pmid:17100567
Kim SJ et al. Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. 2006 Arch. Pharm. Res. pmid:17121182
Kowalski ML Aspirin-sensitive rhinosinusitis and asthma. 2007 Clin Allergy Immunol pmid:17153012
Bakos E and Homolya L Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). 2007 Pflugers Arch. pmid:17187268
Yang SL and Lou YJ Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. 2007 Biochem. Pharmacol. pmid:17194456
Yoshisue H et al. Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. 2007 J. Allergy Clin. Immunol. pmid:17208594
Lee KS et al. Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. 2007 J. Allergy Clin. Immunol. pmid:17208595
Nuutinen P et al. Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals. 2007 Acta Derm. Venereol. pmid:17225008
Blanchet MR et al. Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. 2007 J. Leukoc. Biol. pmid:17289799
Mortaz E et al. Stimulation of cysteinyl leukotriene production in mast cells by heat shock and acetylsalicylic acid. 2007 Eur. J. Pharmacol. pmid:17306251
Liebhart J et al. Production of leukotriene C4 by peripheral blood leukocytes stimulated with anti-fcepsilonRI antibody, PMA, and fMLP does not correlate with irreversible airway obstruction in asthmatics. 2007 J Investig Allergol Clin Immunol pmid:17323856
Rao NL et al. Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. 2007 J. Pharmacol. Exp. Ther. pmid:17371808
Yang SL et al. Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. 2007 J. Surg. Res. pmid:17397868
Yang JJ et al. Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. 2007 Pharm. Res. pmid:17404811
Ebihara S et al. A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. 2007 Inflamm. Res. pmid:17406808
Liu YG and Luo JB [Effects of among compositions of Herba Ephedrae decoction on genic xpression of 5-lipoxygenase activating protein, IL-4 and leukotriene C4 in asthmatic mice]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17432150
Zhang XC et al. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. 2007 J. Pharmacol. Exp. Ther. pmid:17483291
Létourneau IJ et al. Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function. 2007 Drug Metab. Dispos. pmid:17494643
Yang SL et al. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. 2007 Pharmacology pmid:17496435
Zhang L et al. Mechanistic study on the intestinal absorption and disposition of baicalein. 2007 Eur J Pharm Sci pmid:17507208
Jame AJ et al. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. 2007 Clin. Exp. Allergy pmid:17517102
Seres I et al. The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. 2006 J. Membr. Biol. pmid:17546512
Perrotton T et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. 2007 J. Biol. Chem. pmid:17646169
Kopp MV et al. Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. 2007 Pediatr Allergy Immunol pmid:17680911
Farias SE et al. Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. 2007 J. Neurochem. pmid:17711426
Laengle UW et al. Effects of latanoprost, timolol and GLC756, a novel dopamine D(2) agonist and D(1) antagonist on LTC(4) release after rat mast cell activation. 2007 Sep-Oct Clin. Experiment. Ophthalmol. pmid:17894685
Wang W et al. Mechanistic study of potentiation of chemotherapy by a haloenol lactone derivative in vitro. 2008 Cancer Chemother. Pharmacol. pmid:17899085
Chang WC et al. All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cells. 2007 J. Immunol. pmid:17911611
Hattori Y et al. Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17947453
Rius M et al. ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4). 2008 J. Pharmacol. Exp. Ther. pmid:17959747
Yang SH and Yu CL Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. 2008 J Ethnopharmacol pmid:17980528
Mustafa FB et al. Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils. 2008 Clin. Exp. Immunol. pmid:18005261
Devakumar A et al. Structural analysis of leukotriene C4 isomers using collisional activation and 157 nm photodissociation. 2008 J. Am. Soc. Mass Spectrom. pmid:18024058
Thompson C et al. Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription. 2008 J. Biol. Chem. pmid:18048362
Slot AJ et al. Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. 2008 Drug Metab. Dispos. pmid:18079363
Chang WC et al. Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. 2008 J. Biol. Chem. pmid:18156181
Feltenmark S et al. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18184802
Wang J et al. Does leukotriene affect intracellular glutathione redox state in cultured human airway epithelial cells? 2008 Antioxid. Redox Signal. pmid:18199004
Cao F et al. Mrp2-related efflux of scutellarin in the intestinal absorption in rats. 2008 Pharmazie pmid:18271309
Korzekwa AJ et al. Luteolytic effect of prostaglandin F 2 alpha on bovine corpus luteum depends on cell composition and contact. 2008 Reprod. Domest. Anim. pmid:18282218
Ito Y et al. Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. 2008 BMB Rep pmid:18315950
Létourneau IJ et al. Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter. 2008 Biochem. Pharmacol. pmid:18336795
Heredi-Szabo K et al. Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4. 2008 J Biomol Screen pmid:18349419
Moon TC et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. 2008 Arch. Pharm. Res. pmid:18365692
Bandler PE et al. Identification of regions required for apical membrane localization of human multidrug resistance protein 2. 2008 Mol. Pharmacol. pmid:18381564
Mochizuki Y et al. Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro. 2008 Jan-Feb In Vivo pmid:18396776
Aleo MD et al. An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity. 2008 Toxicol. Appl. Pharmacol. pmid:18407308
Zheng MS et al. Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. 2008 Arch. Pharm. Res. pmid:18409044
Bäck M Cysteinyl-leukotrienes in cerebrovascular disease: angels and demons? 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18421005
Ma KF et al. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. 2008 World J. Gastroenterol. pmid:18461660
Mishra NC et al. Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. 2008 J. Immunol. pmid:18490768
Mueller CF et al. Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export. 2008 Circulation pmid:18506003
Chaung HC et al. Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. 2009 Res. Vet. Sci. pmid:18565553
Marchan R et al. Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release. 2008 Biochim. Biophys. Acta pmid:18621020
Yang R et al. Interaction between the bound Mg.ATP and the Walker A serine residue in NBD2 of multidrug resistance-associated protein MRP1 plays a crucial role for the ATP-dependent leukotriene C4 transport. 2008 Biochemistry pmid:18636743
Reichel V et al. Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. 2008 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:18650317
Niwa Y et al. Opposite effects of PU.1 on mast cell stimulation. 2008 Biochem. Biophys. Res. Commun. pmid:18680724
Kirshenbaum AS et al. Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition. 2008 BMC Immunol. pmid:18687131
Rothnie A et al. Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport. 2008 Mol. Pharmacol. pmid:18768387
Grant CE et al. Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). 2008 Drug Metab. Dispos. pmid:18775981
Tan Y and Lim LH trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation. 2008 Br. J. Pharmacol. pmid:18776917
Blokzijl H et al. Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease. 2008 J. Biol. Chem. pmid:18838379
Maekawa A et al. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18931305
Pecaric-Petkovic T et al. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. 2009 Blood pmid:18955562