| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Iram SH and Cole SP | Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). | 2012 | J. Biol. Chem. | pmid:22232552 |
| Han YS et al. | Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells. | 2012 | Inflammation | pmid:22729280 |
| Dellon ES et al. | Diagnostic utility of major basic protein, eotaxin-3, and leukotriene enzyme staining in eosinophilic esophagitis. | 2012 | Am. J. Gastroenterol. | pmid:22777338 |
| Nagy E et al. | Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22450322 |
| Kar P et al. | Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22509043 |
| Qin L et al. | Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function. | 2012 | Drug Metab. Dispos. | pmid:22511347 |
| Nunomura S et al. | The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L. | 2012 | J. Immunol. | pmid:22430736 |
| Stolarczyk EI et al. | Casein kinase 2α regulates multidrug resistance-associated protein 1 function via phosphorylation of Thr249. | 2012 | Mol. Pharmacol. | pmid:22695718 |
| Lu Y et al. | Citreorosein inhibits degranulation and leukotriene Câ‚„ generation through suppression of Syk pathway in mast cells. | 2012 | Mol. Cell. Biochem. | pmid:22395859 |
| Kidron H et al. | Impact of probe compound in MRP2 vesicular transport assays. | 2012 | Eur J Pharm Sci | pmid:22406294 |
| Oyoshi MK et al. | Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22416124 |
| Jin Y et al. | Pinusolide isolated from Biota orientalis inhibits 5-lipoxygenase dependent leukotriene C4 generation by blocking c-Jun N-terminal kinase pathway in mast cells. | 2012 | Biol. Pharm. Bull. | pmid:22863941 |
| Ilarraza R et al. | Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro. | 2012 | Int. Arch. Allergy Immunol. | pmid:22846852 |
| Mackay GA and Stewart AG | R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC(4) production by human eosinophils. | 2011 | Br. J. Pharmacol. | pmid:21426314 |
| Shaari K et al. | Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase. | 2011 | Bioorg. Med. Chem. | pmid:21958738 |
| Lu Y et al. | Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. | 2011 | Biochem. Pharmacol. | pmid:21907188 |
| Iram SH and Cole SP | Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2. | 2011 | J. Biol. Chem. | pmid:21177244 |
| Vieira-de-Abreu A et al. | Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene Câ‚„-synthesizing lipid bodies. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20539011 |
| Al-Amran FG et al. | Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats. | 2011 | J Cardiothorac Surg | pmid:21649921 |
| Jin M et al. | Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. | 2011 | Arch. Pharm. Res. | pmid:21975811 |