LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Wu L et al. Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. 2012 J. Mol. Neurosci. pmid:22661361
Eaton A et al. Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression. 2012 J. Mol. Med. pmid:22527886
Zhou M et al. In vivo intranasal anti-CD23 treatment inhibits allergic responses in a murine model of allergic rhinitis. 2013 J. Mol. Histol. pmid:23377922
Becher UM et al. Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. 2011 J. Mol. Cell. Cardiol. pmid:21112334
Seres I et al. The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. 2006 J. Membr. Biol. pmid:17546512
Seno K et al. Pyrrolidine inhibitors of human cytosolic phospholipase A(2). 2000 J. Med. Chem. pmid:10737736
Mayatepek E et al. Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. 2004 J. Lipid Res. pmid:14754911
Dichlberger A et al. Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. 2014 J. Lipid Res. pmid:25114172
Sjölinder M et al. Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. 1999 J. Lipid Res. pmid:10064732
Lukic A et al. Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. 2016 J. Lipid Res. pmid:27436590
Gibbs BF et al. Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. 2002 J. Leukoc. Biol. pmid:12149431
Oliveira SH et al. Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. 2002 J. Leukoc. Biol. pmid:12050188
Inoue T et al. Nitric Oxide positively regulates Ag (I)-induced Ca(2+) influx and mast cell activation: role of a Nitric Oxide Synthase-independent pathway. 2009 J. Leukoc. Biol. pmid:19706839
Raible DG Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. 1994 J. Leukoc. Biol. pmid:8027672
Gibbs BF and Grabbe J Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. 1999 J. Leukoc. Biol. pmid:10380914
Blanchet MR et al. Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. 2007 J. Leukoc. Biol. pmid:17289799
Hom JT et al. The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils. 1995 J. Leukoc. Biol. pmid:7595053
Malaviya R and Abraham SN Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. 2000 J. Leukoc. Biol. pmid:10857857
Tsuruta R et al. Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. 1999 J. Leukoc. Biol. pmid:9886248
Rossi A et al. Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}. 2005 J. Leukoc. Biol. pmid:16046553
Kobayashi H et al. Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. 1998 J. Lab. Clin. Med. pmid:9579392
Horikawa T et al. Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. 1995 J. Invest. Dermatol. pmid:7530272
Cederholm T et al. Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. 2000 J. Intern. Med. pmid:10886494
Sichletidis L et al. Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. 1993 Mar-Apr J. Int. Med. Res. pmid:8243793
Mayatepek E et al. Acute metabolic crisis with extreme deficiency of glutathione in combination with decreased levels of leukotriene C4 in a patient with glutathione synthetase deficiency. 2004 J. Inherit. Metab. Dis. pmid:15243994
Mayatepek E et al. Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. 2000 J. Inherit. Metab. Dis. pmid:10896305
Mayatepek E et al. LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. 1999 J. Infect. Dis. pmid:9952384
Li GQ et al. Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation. 2006 J. Infect. Dis. pmid:16518767
Sedgwick JB et al. Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. 1996 J. Immunol. Methods pmid:8914593
Laviolette M et al. Comparison of two modified techniques for purifying blood eosinophils. 1993 J. Immunol. Methods pmid:8228275
Volland H et al. Enzyme immunometric assay for leukotriene C4. 1994 J. Immunol. Methods pmid:7930643
Tsang S et al. Simplified purification of human basophils. 2000 J. Immunol. Methods pmid:10648851
Miura K et al. Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. 2001 J. Immunol. pmid:11490016
Muñoz NM et al. Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. 2006 J. Immunol. pmid:16785555
Nguyen T and Gupta S Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. 1997 J. Immunol. pmid:9144509
Chibana K et al. Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. 2003 J. Immunol. pmid:12682264
Serio KJ et al. Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1. 2003 J. Immunol. pmid:12574384
MacGlashan DW and Hubbard WC IL-3 alters free arachidonic acid generation in C5a-stimulated human basophils. 1993 J. Immunol. pmid:8245471
Egger D et al. IL-4 renders mast cells functionally responsive to endothelin-1. 1995 J. Immunol. pmid:7530742
Weber M et al. Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. 1995 J. Immunol. pmid:7535823
Kita H et al. Does IgE bind to and activate eosinophils from patients with allergy? 1999 J. Immunol. pmid:10352312
Suzuki Y et al. Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. 2002 J. Immunol. pmid:12244196
Bandeira-Melo C et al. Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. 2000 J. Immunol. pmid:10623853
Miura K et al. Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. 1999 J. Immunol. pmid:10201947
Nagata M et al. Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. 1995 J. Immunol. pmid:7543540
Campbell EM et al. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. 1999 J. Immunol. pmid:10438957
Okayama Y et al. A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. 2001 J. Immunol. pmid:11254731
Dartt DA et al. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. 2011 J. Immunol. pmid:21357260
Vilariño N et al. Acute IL-3 priming up-regulates the stimulus-induced Raf-1-Mek-Erk cascade independently of IL-3-induced activation of Erk. 2005 J. Immunol. pmid:16116188
Duffy SM et al. Resting and activation-dependent ion channels in human mast cells. 2001 J. Immunol. pmid:11591748