| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Loe DW et al. | Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. | 1996 | J. Biol. Chem. | pmid:8621643 |
| Pulaski L et al. | Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes. | 1996 | Eur. J. Biochem. | pmid:8917467 |
| Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
| Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
| Ruf G et al. | Aminoterminal propeptide of type III procollagen: a marker of hepatic fibrosis after bile duct obstruction in the monkey. | 1996 Jan-Feb | Hepatogastroenterology | pmid:8682446 |
| Cortijo J et al. | Bronchodilator and anti-inflammatory activities of SCA40: studies in human isolated bronchus, human eosinophils, and in the guinea-pig in vivo. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9453467 |
| Sabbah A et al. | [Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases]. | 1997 | Allerg Immunol (Paris) | pmid:9221011 |
| Leynadier F | [Drug allergies: value of the leucotriene C4 release test?]. | 1997 | Presse Med | pmid:9180883 |
| Forssmann U et al. | Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. | 1997 | J. Exp. Med. | pmid:9182688 |
| Scoggan KA et al. | Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. | 1997 | J. Biol. Chem. | pmid:9092565 |
| Carter BZ et al. | Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. | 1997 | J. Biol. Chem. | pmid:9139674 |
| KuÅŸtimur S et al. | Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150373 |
| Frieling T et al. | Leukotriene-evoked cyclic chloride secretion is mediated by enteric neuronal modulation in guinea-pig colon. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9151302 |
| Takano T et al. | Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. | 1997 | J. Exp. Med. | pmid:9151906 |
| Hardcastle JE and Bruch RJ | Effect of L-aspartyl-L-phenylalanine methyl ester on leukotriene biosynthesis in macrophage cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384524 |
| Pedersen KE et al. | Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9152370 |
| Abe T et al. | [Multidrug resistance protein (MRP)]. | 1997 | Nippon Rinsho | pmid:9155156 |
| Gagari E et al. | Differential release of mast cell interleukin-6 via c-kit. | 1997 | Blood | pmid:9108382 |
| Ohtsuka Y et al. | Reducing cell membrane n-6 fatty acids attenuate mucosal damage in food-sensitive enteropathy in mice. | 1997 | Pediatr. Res. | pmid:9396566 |
| Madon J et al. | Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. | 1997 | FEBS Lett. | pmid:9109389 |
| Sala A et al. | Pharmacological modulation of human platelet leukotriene C4-synthase. | 1997 | Biochem. Pharmacol. | pmid:9113110 |
| de Paulis A et al. | Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. | 1997 | Arthritis Rheum. | pmid:9082935 |
| Nguyen T and Gupta S | Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. | 1997 | J. Immunol. | pmid:9144509 |
| Bozkurt S et al. | The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9144840 |
| Genovese A et al. | Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. | 1997 | Clin. Exp. Allergy | pmid:9179431 |
| Puder M and Soberman RJ | Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. | 1997 | J. Biol. Chem. | pmid:9099752 |
| Wang D et al. | An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. | 1997 | Allergy | pmid:9105520 |
| Sumizawa T et al. | Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. | 1997 | Mol. Pharmacol. | pmid:9058594 |
| Ibe BO et al. | Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. | 1997 | Biochem. Mol. Med. | pmid:9232199 |
| Brady HR et al. | Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. | 1997 | Adv. Exp. Med. Biol. | pmid:9547614 |
| Herman CA et al. | Synthesis and action of eicosanoids in warm and cold-acclimated amphibians. | 1997 | Adv. Exp. Med. Biol. | pmid:9561172 |
| Sporn PH et al. | Keratinocyte growth factor increases LTC4 synthesis and expression of flap in cultured rat alveolar type II cells. | 1997 | Adv. Exp. Med. Biol. | pmid:9561179 |
| Monahan J et al. | Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. | 1997 | J. Immunol. | pmid:9378992 |
| Vigorito C et al. | Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man. | 1997 | Int. J. Clin. Lab. Res. | pmid:9352380 |
| Jedlitschky G et al. | ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. | 1997 | Biochem. J. | pmid:9355767 |
| Damtew B and Spagnuolo PJ | Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051719 |
| Cunningham FM et al. | Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse. | 1997 | J. Vet. Pharmacol. Ther. | pmid:9280370 |
| el-Ahmady O et al. | Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. | 1997 | Ann. Clin. Biochem. | pmid:9133249 |
| Bureau MF et al. | 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. | 1997 | Eur. J. Pharmacol. | pmid:9137918 |
| Zeltsman D et al. | Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. | 1997 | Shock | pmid:9110414 |
| Kitaura K et al. | Effects of organic anions and bile acid conjugates on biliary excretion of LTC4 in the rat. | 1997 | Prostaglandins | pmid:9491205 |
| Bell RR et al. | Cadmium and/or selenium effects on guinea pig lung PGE2, TXB2 and LTC4. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9344235 |
| Taichman RS et al. | Human osteosarcomas inhibit hematopoietic colony formation: partial reversal by antibody to transforming growth factor-beta 1. | 1997 | Bone | pmid:9315339 |
| Hsueh W et al. | Injurious and protective mechanisms in the gut. Interaction of PAF, phospholipase A2, eicosanoids, and nitric oxide synthase. | 1997 | Adv. Exp. Med. Biol. | pmid:9321977 |
| Chow JY et al. | The potentiating actions of cigarette smoking on ethanol-induced gastric mucosal damage in rats. | 1997 | Gastroenterology | pmid:9322514 |
| Keppler D et al. | The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes. | 1997 | Adv. Enzyme Regul. | pmid:9381978 |
| Bailey JM et al. | Activation of mitogen-induced T-lymphocyte proliferation by leukotriene C-4. | 1997 | Biochem. Soc. Trans. | pmid:9388724 |
| Zweiman B et al. | Nasal airway changes assessed by acoustic rhinometry and mediator release during immediate and late reactions to allergen challenge. | 1997 | J. Allergy Clin. Immunol. | pmid:9389292 |
| Bacha EA et al. | Gastric antigen challenge releases gastrin and eicosanoids and protects against ethanol. | 1997 | J. Surg. Res. | pmid:9228931 |
| Hamasaki Y et al. | The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1997 | J Ethnopharmacol | pmid:9174973 |