| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Aspergillosis, Allergic Bronchopulmonary | D001229 | 2 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hemelaers L et al. | Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics. | 2006 | Allergy | pmid:16364169 |
| Mezhybovska M et al. | The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. | 2006 | J. Biol. Chem. | pmid:16407243 |
| Carvajal MT and Staniforth JN | Interactions of water with the surfaces of crystal polymorphs. | 2006 | Int J Pharm | pmid:16298501 |
| Ravasi S et al. | CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. | 2006 | Respir. Res. | pmid:16553950 |
| Bouchelouche K and Bouchelouche P | Cysteinyl leukotriene D4 increases human detrusor muscle responsiveness to histamine. | 2006 | J. Urol. | pmid:16753444 |
| Thompson C et al. | CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16809637 |
| Paruchuri S et al. | Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells. | 2006 | Oncogene | pmid:16715140 |
| Wang ML et al. | Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17010308 |
| Mezhybovska M et al. | Pro-inflammatory mediator leukotriene D4 induces transcriptional activity of potentially oncogenic genes. | 2005 | Biochem. Soc. Trans. | pmid:16042577 |
| Kato J et al. | Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. | 2005 | Clin. Immunol. | pmid:16109507 |