LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Respirovirus Infections D010253 3 associated lipids
Nasal Obstruction D015508 4 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Sneezing D012912 6 associated lipids
Asbestosis D001195 8 associated lipids
Enteritis D004751 8 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Rhinitis D012220 10 associated lipids
Influenza, Human D007251 11 associated lipids
Airway Obstruction D000402 13 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Carotid Stenosis D016893 15 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Cough D003371 19 associated lipids
Brain Edema D001929 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

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Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Smyth TP et al. A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase. 2003 Bioorg. Med. Chem. pmid:12614884
Wikström K et al. The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. 2003 Biochem. J. pmid:12482325
Kawano T et al. Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. 2003 J. Allergy Clin. Immunol. pmid:12897744
Paruchuri S and Sjölander A Leukotriene D4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. 2003 J. Biol. Chem. pmid:12912998
Suzuki M et al. Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078). 2003 J Asthma pmid:12870835
Massoumi R et al. Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. 2003 Exp. Cell Res. pmid:14499635
Thompson MD et al. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. 2003 Pharmacogenetics pmid:14515063
Capra V et al. Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. 2003 Prostaglandins Other Lipid Mediat. pmid:14518564
Schuhmann MU et al. Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. 2003 Neurol. Res. pmid:12866196
Marusova IB et al. [Potential gastroprotective effect of a CysLT1 receptor blocker sodium montelukast in aspirin-induced lesions of the rat stomach mucosa]. 2002 May-Jun Eksp Klin Farmakol pmid:12227087
Braccioni F et al. The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. 2002 J. Allergy Clin. Immunol. pmid:12110827
Uemura M et al. Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. 2002 J. Gastroenterol. pmid:12424566
Stelmach I et al. [The effect of inhaled heparin on post-leukotriene bronchoconstriction in children with bronchial asthma]. 2002 Pol. Merkur. Lekarski pmid:11995261
Allakhverdi Z et al. Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma. 2002 Am. J. Respir. Crit. Care Med. pmid:11934731
Lavoie JP et al. Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. 2002 Am. J. Vet. Res. pmid:11939323
Nagata M et al. Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. 2002 J. Allergy Clin. Immunol. pmid:11941318
Evans JF Cysteinyl leukotriene receptors. 2002 Prostaglandins Other Lipid Mediat. pmid:12432945
Ketchell RI et al. Contrasting effects of allergen challenge on airway responsiveness to cysteinyl leukotriene D(4) and methacholine in mild asthma. 2002 Thorax pmid:12096198
Shirasaki H et al. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. 2002 Clin. Exp. Allergy pmid:12100046
Thodeti CK et al. Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. 2002 Biochem. J. pmid:12071848