Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Jiang Y et al. | CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. | 2007 | Blood | pmid:17693579 |
Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |
Tokuriki S et al. | Leukotriene D(4) enhances the function of endothelin-1-primed fibroblasts. | 2007 | Clin. Immunol. | pmid:17627891 |
Schelfhout V et al. | The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. | 2008 | Pulm Pharmacol Ther | pmid:17611132 |
Peng F et al. | [Cysteinyl leukotriene receptor 1 antagonist pranlukast modulates differentiation of SK-N-SH cells]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17443897 |
Hu X et al. | [Effects of cysteinyl receptor agonist and antagonists on rat primary cortical neurons]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17443896 |
Skogvall S et al. | Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. | 2008 | Pulm Pharmacol Ther | pmid:17374498 |
Bai CH et al. | The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells. | 2007 | Auris Nasus Larynx | pmid:17223000 |
Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
Yang YY et al. | Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis. | 2007 | Clin. Sci. | pmid:17176248 |
Stengel PW et al. | Inhaled anandamide reduces leukotriene D4-induced airway obstruction in guinea pigs. | 2007 | Eur. J. Pharmacol. | pmid:17166495 |
Goto HG et al. | Induction of apoptosis in an estrogen-responsive mouse Leydig tumor cell by leukotriene. | 2007 | Oncol. Rep. | pmid:17143502 |
Ishimura M et al. | Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. | 2006 | Allergol Int | pmid:17130683 |
Chiba Y et al. | Regional differences in vascular responsiveness of nasal mucosae isolated from naive guinea pigs. | 2007 | Auris Nasus Larynx | pmid:17056219 |
Wang ML et al. | Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17010308 |
Chiba Y et al. | Impaired norepinephrine-mediated contraction of isolated nasal mucosa in guinea pigs with allergic rhinitis. | 2006 Jul-Aug | Am J Rhinol | pmid:16955783 |
Tanaka Y et al. | Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939879 |
Nieves D and Moreno JJ | Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation. | 2006 | Biochem. Pharmacol. | pmid:16934759 |
Hoopes C | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16928544 |