Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bandeira-Melo C et al. | Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. | 2002 | J. Exp. Med. | pmid:12235216 |
Marusova IB et al. | [Potential gastroprotective effect of a CysLT1 receptor blocker sodium montelukast in aspirin-induced lesions of the rat stomach mucosa]. | 2002 May-Jun | Eksp Klin Farmakol | pmid:12227087 |
McMahon B et al. | Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. | 2002 | FASEB J. | pmid:12223454 |
Han B et al. | Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. | 2002 | Am. J. Pathol. | pmid:12163373 |
Massoumi R et al. | Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta. | 2002 | J. Cell. Sci. | pmid:12154081 |
Li PC et al. | Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. | 2002 | J. Cell. Physiol. | pmid:12115725 |
Braccioni F et al. | The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. | 2002 | J. Allergy Clin. Immunol. | pmid:12110827 |
Shirasaki H et al. | Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. | 2002 | Clin. Exp. Allergy | pmid:12100046 |
Ketchell RI et al. | Contrasting effects of allergen challenge on airway responsiveness to cysteinyl leukotriene D(4) and methacholine in mild asthma. | 2002 | Thorax | pmid:12096198 |
Li X and Weinman SA | Mrp2 modulates the activity of chloride channels in isolated hepatocytes. | 2002 | Hepatology | pmid:12085350 |
Bäck M | Functional characteristics of cysteinyl-leukotriene receptor subtypes. | 2002 | Life Sci. | pmid:12072150 |
Thodeti CK et al. | Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. | 2002 | Biochem. J. | pmid:12071848 |
Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
Terada T et al. | Effect of oral antigen administration on nasal blockage in experimental allergic rhinitis in guinea pigs. | 2002 | Inflamm. Res. | pmid:12058959 |
Nag S et al. | Interleukin-2-induced increased airway responsiveness and lung Th2 cytokine expression occur after antigen challenge through the leukotriene pathway. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12045130 |
Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |
Stelmach I et al. | [The effect of inhaled heparin on post-leukotriene bronchoconstriction in children with bronchial asthma]. | 2002 | Pol. Merkur. Lekarski | pmid:11995261 |
Paruchuri S et al. | Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells. | 2002 | J. Cell. Sci. | pmid:11956320 |
Nagata M et al. | Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. | 2002 | J. Allergy Clin. Immunol. | pmid:11941318 |
Lavoie JP et al. | Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. | 2002 | Am. J. Vet. Res. | pmid:11939323 |