Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Undem BJ et al. | Recombinant stem cell factor-induced mast cell activation and smooth muscle contraction in human bronchi. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:7524570 |
Kargman S et al. | Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. | 1994 | Mol. Pharmacol. | pmid:8190095 |
Nabe T et al. | Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7824530 |
Sjölander A and Grönroos E | Leukotriene D4-induced signal transduction. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825836 |
Krell RD et al. | Preclinical exploration of the potential antiinflammatory properties of the peptide leukotriene antagonist ICI 204,219 (Accolate). | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825851 |
Wensing G et al. | Effect of BAY x 7195, an oral receptor antagonist of cysteinyl-leukotrienes, on leukotriene D4-induced bronchoconstriction in normal volunteers. | 1994 | Eur. J. Clin. Pharmacol. | pmid:7867675 |
Petric R and Ford-Hutchinson AW | Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. | 1994 | Kidney Int. | pmid:7853790 |
Leier I et al. | The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. | 1994 | J. Biol. Chem. | pmid:7961706 |
An S et al. | Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4. | 1994 | Biochim. Biophys. Acta | pmid:8054366 |
Tsopanoglou NE et al. | Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. | 1994 | Eur. J. Pharmacol. | pmid:7523148 |
Metters KM et al. | Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8035338 |
Diener M and Scharrer E | The effect of short-chain fatty acids on Cl- and K+ conductance in rat colonic crypts. | 1994 | Pflugers Arch. | pmid:8052516 |
Chan CC et al. | Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. | 1994 | Can. J. Physiol. Pharmacol. | pmid:8012892 |
Diamant Z et al. | Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. | 1994 | Eur. Respir. J. | pmid:8013602 |
Chan CC et al. | Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8014876 |
Arakawa H et al. | Effect of maturation on airway plasma exudation induced by eicosanoids in guinea pig. | 1994 | Eur. J. Pharmacol. | pmid:7982451 |
Kelley M et al. | Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. | 1994 | Fundam Appl Toxicol | pmid:7982537 |
Kurosawa M et al. | Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. | 1994 | Clin. Exp. Allergy | pmid:7842366 |
Herd CM et al. | Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. | 1994 | Br. J. Pharmacol. | pmid:8032653 |
Thioudellet C et al. | Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. | 1994 | Eur. J. Biochem. | pmid:7913033 |