Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ishimura M et al. | Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. | 2006 | Allergol Int | pmid:17130683 |
Thivierge M et al. | Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. | 2006 | J. Allergy Clin. Immunol. | pmid:16675346 |
Abe M et al. | A novel method for preserving human lungs using a super-cooling system. | 2006 | Ann. Thorac. Surg. | pmid:16928543 |
Hoopes C | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16928544 |
Dahlén SE | Treatment of asthma with antileukotrienes: first line or last resort therapy? | 2006 | Eur. J. Pharmacol. | pmid:16510137 |
Gyllfors P et al. | Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. | 2006 | J. Allergy Clin. Immunol. | pmid:16815141 |
Mezhybovska M et al. | The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. | 2006 | J. Biol. Chem. | pmid:16407243 |
Nieves D and Moreno JJ | Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation. | 2006 | Biochem. Pharmacol. | pmid:16934759 |
Carvajal MT and Staniforth JN | Interactions of water with the surfaces of crystal polymorphs. | 2006 | Int J Pharm | pmid:16298501 |
Cui S et al. | Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liver. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16846785 |
Tanaka Y et al. | Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigs. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939879 |
Chiba Y et al. | Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa. | 2006 | Nitric Oxide | pmid:16442819 |
Lefebvre B et al. | Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. | 2006 | J. Hypertens. | pmid:16331105 |
Rovati GE et al. | Cysteinyl-leukotrienes in the regulation of beta2-adrenoceptor function: an in vitro model of asthma. | 2006 | Respir. Res. | pmid:16875498 |
Thompson C et al. | CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16809637 |
Paruchuri S et al. | Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells. | 2006 | Oncogene | pmid:16715140 |
Wang ML et al. | Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17010308 |
Shimoda H et al. | Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. | 2006 | J. Agric. Food Chem. | pmid:16608208 |
Neves JS et al. | Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats. | 2005 | Eur. J. Pharmacol. | pmid:15792791 |
Naik S et al. | Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. | 2005 | J. Biol. Chem. | pmid:15590629 |