LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Airway Obstruction D000402 13 associated lipids
Asbestosis D001195 8 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Asthma D001249 52 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Body Weight D001835 333 associated lipids
Brain Edema D001929 20 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Edema D004487 152 associated lipids
Enteritis D004751 8 associated lipids
Gastritis D005756 27 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Inflammation D007249 119 associated lipids
Influenza, Human D007251 11 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Busse WW et al. Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease. 1999 Clin. Exp. Allergy pmid:10421833
Shirasaki H et al. Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. 2002 Clin. Exp. Allergy pmid:12100046
Heimbürger M and Palmblad JE Effects of leukotriene C4 and D4, histamine and bradykinin on cytosolic calcium concentrations and adhesiveness of endothelial cells and neutrophils. 1996 Clin. Exp. Immunol. pmid:8608646
Joki S and Saano V Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium. 1997 Clin. Exp. Pharmacol. Physiol. pmid:9075591
Ohbayashi H et al. Neutral endopeptidase 3.4.24.11 inhibition potentiates the inhibitory effects of type-C natriuretic peptide on leukotriene D4-induced airway changes. 1998 Clin. Exp. Pharmacol. Physiol. pmid:9887994
Trandafir CC et al. Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. 2005 Clin. Exp. Pharmacol. Physiol. pmid:16445567
Tokuriki S et al. Leukotriene D(4) enhances the function of endothelin-1-primed fibroblasts. 2007 Clin. Immunol. pmid:17627891
Kato J et al. Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. 2005 Clin. Immunol. pmid:16109507
Smith LJ et al. Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. 1993 Clin. Pharmacol. Ther. pmid:8222486
Yang YY et al. Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis. 2007 Clin. Sci. pmid:17176248