| MeSH term | MeSH ID | Detail |
|---|---|---|
| Endotoxemia | D019446 | 27 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Nasal Obstruction | D015508 | 4 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Peptic Ulcer Hemorrhage | D010438 | 4 associated lipids |
| Respirovirus Infections | D010253 | 3 associated lipids |
| Otitis Media with Effusion | D010034 | 9 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Austen KF et al. | The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. | 2009 | J. Allergy Clin. Immunol. | pmid:19647860 |
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| Hori M et al. | NT-702 (parogrelil hydrochloride, NM-702), a novel and potent phosphodiesterase 3 inhibitor, suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. | 2009 | Eur. J. Pharmacol. | pmid:19616537 |
| Yang HS et al. | [Effects of leukotriene receptor antagonists on vascular endothelial growth factor and its receptors in a sensitized rat model]. | 2009 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:19575935 |
| Maekawa A et al. | GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19561298 |
| Mori M et al. | Eosinophil superoxide anion generation induced by adhesion molecules and leukotriene D4. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494502 |
| Lee TH et al. | Leukotriene E4: perspective on the forgotten mediator. | 2009 | J. Allergy Clin. Immunol. | pmid:19482346 |
| Boehmler AM et al. | The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells. | 2009 | J. Immunol. | pmid:19454674 |
| Baker N et al. | Lipoxin A4: anti-inflammatory and anti-angiogenic impact on endothelial cells. | 2009 | J. Immunol. | pmid:19265161 |
| Yuan YM et al. | Leukotriene D4 stimulates the migration but not proliferation of endothelial cells mediated by the cysteinyl leukotriene cyslt(1) receptor via the extracellular signal-regulated kinase pathway. | 2009 | J. Pharmacol. Sci. | pmid:19234368 |
| Campos MR et al. | Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. | 2009 | Mol. Immunol. | pmid:19223078 |
| Hashimoto K et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. | 2009 | Int. Arch. Allergy Immunol. | pmid:19218821 |
| Theron AJ et al. | Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. | 2009 | Inflamm. Res. | pmid:19184354 |
| Broom OJ and Nielsen OH | [The role of cysteinyl leukotrienes in chronic inflammation and neoplasia of the intestine]. | 2009 | Ugeskr. Laeg. | pmid:19174041 |
| Claesson HE | On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19130894 |
| Fang SH et al. | Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19129732 |
| Dayyat E et al. | Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. | 2009 | Chest | pmid:19118273 |
| Lee SP et al. | Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. | 2009 | J. Immunol. | pmid:19109185 |
| Selg E et al. | Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19103301 |
| Schain F et al. | Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas. | 2008 | Clin Lymphoma Myeloma | pmid:19064398 |
| Yudina Y et al. | Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19042113 |
| Mizutani N et al. | Effect of TA-270, a novel quinolinone derivative, on antigen-induced nasal blockage in a guinea pig model of allergic rhinitis. | 2009 | Eur. J. Pharmacol. | pmid:19022242 |
| Lecca D et al. | The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. | 2008 | PLoS ONE | pmid:18974869 |
| Maekawa A et al. | Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18931305 |
| Rehni AK et al. | Pharmacological modulation of leukotriene D(4) attenuates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome. | 2008 | Eur. J. Pharmacol. | pmid:18840427 |
| Schain F et al. | Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma. | 2008 | Int. J. Cancer | pmid:18704935 |
| Tamaoka M et al. | The epidermal growth factor receptor mediates allergic airway remodelling in the rat. | 2008 | Eur. Respir. J. | pmid:18653647 |
| pmid:18651869 | ||||
| Claesson HE et al. | Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma. | 2008 | FEBS J. | pmid:18647347 |
| Taylor-Clark TE et al. | Leukotriene D4 increases the excitability of capsaicin-sensitive nasal sensory nerves to electrical and chemical stimuli. | 2008 | Br. J. Pharmacol. | pmid:18500362 |
| Woszczek G et al. | IL-10 inhibits cysteinyl leukotriene-induced activation of human monocytes and monocyte-derived dendritic cells. | 2008 | J. Immunol. | pmid:18490762 |
| Talukder JR et al. | Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18436626 |
| Paruchuri S et al. | Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. | 2008 | J. Biol. Chem. | pmid:18411276 |
| Thompson C et al. | Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18323532 |
| Ito Y et al. | Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4. | 2008 | BMB Rep | pmid:18315950 |
| Profita M et al. | Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18305014 |
| Macdonald D et al. | Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18276139 |
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| Mizutani N et al. | Involvement of peroxynitrite in pollen-induced nasal blockage in guinea pigs. | 2008 | Eur. J. Pharmacol. | pmid:18191833 |
| Suzuki S et al. | Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells. | 2008 | Pharmacology | pmid:18176092 |
| Ge H et al. | Elucidation of signaling and functional activities of an orphan GPCR, GPR81. | 2008 | J. Lipid Res. | pmid:18174606 |
| Bengtsson AM et al. | Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18083053 |
| Ishimura M et al. | Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs. | 2008 | Br. J. Pharmacol. | pmid:18037905 |
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| Bossé Y et al. | Leukotriene D4-induced, epithelial cell-derived transforming growth factor beta1 in human bronchial smooth muscle cell proliferation. | 2008 | Clin. Exp. Allergy | pmid:18028462 |
| Lötzer K et al. | 5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991613 |
| Shirasaki H et al. | Agonist- and T(H)2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes. | 2007 | Ann. Allergy Asthma Immunol. | pmid:17941281 |
| Peres CM et al. | Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. | 2007 | J. Immunol. | pmid:17911632 |
| Huang XJ et al. | Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. | 2008 | Glia | pmid:17910051 |
| Morishima H et al. | Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells. | 2008 | Int. Arch. Allergy Immunol. | pmid:17851256 |