Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Reiss TF et al. | Effects of montelukast (MK-0476), a new potent cysteinyl leukotriene (LTD4) receptor antagonist, in patients with chronic asthma. | 1996 | J. Allergy Clin. Immunol. | pmid:8828530 |
Patry C et al. | Leukotriene receptors in HL-60 cells differentiated into eosinophils, monocytes and neutrophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8832765 |
Shikada K and Tanaka S | Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. | 1996 | Prostaglandins | pmid:8792445 |
Dudek SM and Friedlander MJ | Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition. | 1996 | Neuron | pmid:8663986 |
Jorgensen NK et al. | Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. | 1996 | J. Membr. Biol. | pmid:8661498 |
Carlton RA et al. | Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525. | 1996 | J Pharm Sci | pmid:8742935 |
Bäck M et al. | The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. | 1996 | Eur. J. Pharmacol. | pmid:8982726 |
Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
Fukai F et al. | Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. | 1996 | Cell Biol. Int. | pmid:8858827 |
Hazel BA et al. | Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone. | 1996 | Environ. Health Perspect. | pmid:9118902 |
Tominaga M et al. | ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819486 |
Hazel BA and Kalf GF | Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor. | 1996 | Recept Signal Transduct | pmid:8933618 |
Brocks DR et al. | The single and multiple dose pharmacokinetics of pranlukast in healthy volunteers. | 1996 | Eur. J. Clin. Pharmacol. | pmid:9010703 |
Gyömber E et al. | Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. | 1996 | J. Gastroenterol. Hepatol. | pmid:8912128 |
Nagase T et al. | Roles of calcitonin gene-related peptide (CGRP) in hyperpnea-induced constriction in guinea pigs. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8912779 |
Gorenne I et al. | Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation. | 1996 | Cell Biol. Toxicol. | pmid:9034615 |
Rajah R et al. | Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. | 1996 | Am. J. Physiol. | pmid:8997273 |
Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |
Funayama T et al. | Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8703483 |
Porreca E et al. | Cysteinyl leukotriene D4 induced vascular smooth muscle cell proliferation: a possible role in myointimal hyperplasia. | 1996 | Thromb. Haemost. | pmid:8819260 |