Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Jorgensen NK et al. | Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. | 1996 | J. Membr. Biol. | pmid:8661498 |
Hendeles L and Marshik PL | Zileuton: a new therapy for asthma or just the first of a new class of drugs. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826576 |
Pedersen KE et al. | Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9152370 |
Sampson SE et al. | Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. | 1997 | Thorax | pmid:9227716 |
Fujita M et al. | Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469641 |
Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
Cincu RN et al. | S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver. | 1997 | Hepatology | pmid:9252142 |
Goldhill J et al. | Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. | 1997 | Am. J. Physiol. | pmid:9176223 |
Sakurai S et al. | Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of [4-[1-(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives. | 1997 | Chem. Pharm. Bull. | pmid:9178522 |
Spector SL | Leukotriene activity modulation in asthma. | 1997 | Drugs | pmid:9279501 |
Gissurarson SR et al. | Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023290 |
Sakurai S et al. | [Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of benzenesulfonamide derivatives]. | 1997 | Yakugaku Zasshi | pmid:9194397 |
O'Shaughnessy TC et al. | Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. | 1997 | Thorax | pmid:9227717 |
Tvaermose-Nielsen O et al. | Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. | 1997 | Bioorg. Med. Chem. | pmid:9061206 |
Ohd JF et al. | Leukotriene D4-induced signalling events in human epithelial cells: G alpha i3 activation and translocation. | 1997 | Adv. Exp. Med. Biol. | pmid:9561113 |
von Sprecher A et al. | CGP57698: a structurally simple, highly potent peptido-leukotriene (pLT) antagonist of the quinoline type. | 1997 | Adv. Exp. Med. Biol. | pmid:9561127 |
Honda I et al. | Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction. | 1997 | Fundam Clin Pharmacol | pmid:9243258 |
Kanli H and Terreros DA | Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus. | 1997 | Acta Physiol. Scand. | pmid:9246390 |
Wong WS et al. | Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336317 |
Muñoz NM et al. | Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105085 |