LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Inflammation D007249 119 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Seizures D012640 87 associated lipids
Stomach Ulcer D013276 75 associated lipids
Leukemia D007938 74 associated lipids
Reperfusion Injury D015427 65 associated lipids
Asthma D001249 52 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glomerulonephritis D005921 35 associated lipids
Neuralgia D009437 28 associated lipids
Endotoxemia D019446 27 associated lipids
Gastritis D005756 27 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Brain Edema D001929 20 associated lipids
Cough D003371 19 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Carotid Stenosis D016893 15 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Airway Obstruction D000402 13 associated lipids
Influenza, Human D007251 11 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Rhinitis D012220 10 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Asbestosis D001195 8 associated lipids
Enteritis D004751 8 associated lipids
Sneezing D012912 6 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Nasal Obstruction D015508 4 associated lipids
Respirovirus Infections D010253 3 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Ahmed T et al. Inhibition of allergic late airway responses by inhaled heparin-derived oligosaccharides. 2000 J. Appl. Physiol. pmid:10797135
Thivierge M et al. IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils. 2000 J. Immunol. pmid:11046055
Babu KS and Salvi SS Aspirin and asthma. 2000 Chest pmid:11083703
Kalf GF Utility of a mouse model for studying the effects of benzene on the myeloid lineage: effects of hydroquinone on a model myeloid system. 2000 J. Toxicol. Environ. Health Part A pmid:11086946
Titos E et al. Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. 2000 Gastroenterology pmid:10982774
Ménard G and Bissonnette EY Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation. 2000 Am. J. Respir. Cell Mol. Biol. pmid:11017925
Arakida Y et al. In vivo pharmacologic profile of YM158, a new dual antagonist for leukotriene D4 and thromboxane A2 receptors. 2000 Jpn. J. Pharmacol. pmid:10887942
McMahon B et al. Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. 2000 J. Biol. Chem. pmid:10869343
Turner DJ et al. Bradykinin-induced airway constriction in guinea-pigs: role of leukotriene D(4). 2000 Pulm Pharmacol Ther pmid:10930357
Fukuyama S et al. Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. 2000 Am. J. Respir. Crit. Care Med. pmid:10852755
Ballart B et al. Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists. 2000 Eur J Med Chem pmid:10858604
Hougaard C et al. K+ currents activated by leukotriene D4 or osmotic swelling in Ehrlich ascites tumour cells. 2000 Pflugers Arch. pmid:10898529
Blain JF and Sirois P Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913229
Laberge S et al. Antigen-induced airway inflammation and hyper-responsiveness does not enhance airway responses to a subsequent antigen challenge in rats. 2000 Respir Med pmid:10714478
Kivity S et al. Eosinophil influx into the airways in patients with exercise-induced asthma. 2000 Respir Med pmid:11192956
Robbiani DF et al. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. 2000 Cell pmid:11114332
Hasday JD et al. Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. 2000 Am. J. Respir. Crit. Care Med. pmid:10764316
Hisamatsu K and Nakajima M Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. 2000 Life Sci. pmid:11105993
White IJ et al. A continuous fluorometric assay for leukotriene D4 hydrolase. 1999 Anal. Biochem. pmid:10075814
Takami M and Tsukada W Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents. 1999 Eur. J. Pharmacol. pmid:10082207