Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ichiyama T et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. | 2005 | Clin. Exp. Allergy | pmid:16164450 |
Neves JS et al. | Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats. | 2005 | Eur. J. Pharmacol. | pmid:15792791 |
Naik S et al. | Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. | 2005 | J. Biol. Chem. | pmid:15590629 |
Capra V et al. | CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. | 2005 | J. Cell. Sci. | pmid:16306225 |
Matsuse H et al. | Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes. | 2005 | Int. Arch. Allergy Immunol. | pmid:16215328 |
Reims A et al. | Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. | 2005 | Scand. J. Gastroenterol. | pmid:15764146 |
Gauvreau GM et al. | Expression of functional cysteinyl leukotriene receptors by human basophils. | 2005 | J. Allergy Clin. Immunol. | pmid:15990778 |
Fernandez J et al. | Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways. | 2005 | Eur. J. Pharmacol. | pmid:16202993 |
Casas A et al. | Leukotriene D4-induced hypoxaemia in asthma is mediated by the cys-leukotriene1 receptor. | 2005 | Eur. Respir. J. | pmid:16135725 |
Gyllfors P et al. | Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. | 2005 | Thorax | pmid:16055619 |