Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Claesson HE | On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19130894 |
Selg E et al. | Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19103301 |
Bengtsson AM et al. | Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18083053 |
Lötzer K et al. | 5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991613 |
Nakanishi Y et al. | Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560121 |
Nishimura H et al. | Acute effects of prostaglandin D2 to induce airflow obstruction and airway microvascular leakage in guinea pigs: role of thromboxane A2 receptors. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11519790 |
Sheller J et al. | The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428688 |
Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
Patry C et al. | Leukotriene receptors in HL-60 cells differentiated into eosinophils, monocytes and neutrophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8832765 |
Blain JF and Sirois P | Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913229 |
Rehni AK and Singh TG | Modulation of leukotriene D4 attenuates the development of seizures in mice. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21641195 |
Aizawa H et al. | Thromboxane A2 antagonist inhibits leukotriene D4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014223 |
Nabe T et al. | Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7824530 |
Yudina Y et al. | Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19042113 |
Inamura T et al. | Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8171072 |
Bochnowicz S and Underwood DC | Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7644563 |
Shikada K and Tanaka S | Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. | 1996 | Prostaglandins | pmid:8792445 |
Hisamatsu K et al. | Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. | 1996 | Prostaglandins | pmid:8900445 |
Ramondt J et al. | Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. | 1995 | Prostaglandins | pmid:7792392 |
Tanaka H et al. | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. | 1995 Nov-Dec | Prostaglandins | pmid:8838238 |