Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bouchelouche K and Bouchelouche P | Cysteinyl leukotriene D4 increases human detrusor muscle responsiveness to histamine. | 2006 | J. Urol. | pmid:16753444 |
Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
Paruchuri S et al. | Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells. | 2006 | Oncogene | pmid:16715140 |
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Lamoureux J et al. | Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. | 2006 | J. Allergy Clin. Immunol. | pmid:16630953 |
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Shimoda H et al. | Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. | 2006 | J. Agric. Food Chem. | pmid:16608208 |
Ravasi S et al. | CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. | 2006 | Respir. Res. | pmid:16553950 |
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Trandafir CC et al. | Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16445567 |
Chiba Y et al. | Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa. | 2006 | Nitric Oxide | pmid:16442819 |
Mezhybovska M et al. | The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. | 2006 | J. Biol. Chem. | pmid:16407243 |
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Mayatepek E et al. | A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. | 2005 | Ann. Neurol. | pmid:16315285 |
Capra V et al. | CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. | 2005 | J. Cell. Sci. | pmid:16306225 |
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Matsuse H et al. | Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes. | 2005 | Int. Arch. Allergy Immunol. | pmid:16215328 |
Fernandez J et al. | Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways. | 2005 | Eur. J. Pharmacol. | pmid:16202993 |
Ichiyama T et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. | 2005 | Clin. Exp. Allergy | pmid:16164450 |
Casas A et al. | Leukotriene D4-induced hypoxaemia in asthma is mediated by the cys-leukotriene1 receptor. | 2005 | Eur. Respir. J. | pmid:16135725 |
Kato J et al. | Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts. | 2005 | Clin. Immunol. | pmid:16109507 |
Gyllfors P et al. | Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis. | 2005 | Thorax | pmid:16055619 |
Mezhybovska M et al. | Pro-inflammatory mediator leukotriene D4 induces transcriptional activity of potentially oncogenic genes. | 2005 | Biochem. Soc. Trans. | pmid:16042577 |
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Gauvreau GM et al. | Expression of functional cysteinyl leukotriene receptors by human basophils. | 2005 | J. Allergy Clin. Immunol. | pmid:15990778 |
Parhamifar L et al. | Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. | 2005 | Carcinogenesis | pmid:15975962 |
Kumasawa F et al. | Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells. | 2005 | Eur. J. Pharmacol. | pmid:15970283 |
Kato Y et al. | Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947480 |
Nagata M et al. | Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947477 |
pmid:15888248 | ||||
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Reims A et al. | Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. | 2005 | Scand. J. Gastroenterol. | pmid:15764146 |
Nielsen CK et al. | A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. | 2005 | Cancer Res. | pmid:15705869 |
Paruchuri S et al. | The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells. | 2005 | J. Biol. Chem. | pmid:15657050 |
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Nakanishi Y et al. | Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560121 |
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Pillai SG et al. | A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. | 2004 | Pharmacogenetics | pmid:15475736 |
Ishinaga H et al. | Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. | 2005 | Pharmacology | pmid:15475658 |
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Carbajal V et al. | LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15377496 |
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Capra V et al. | CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras. | 2004 | Biochem. Pharmacol. | pmid:15041474 |
Wulff T et al. | Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. | 2004 | Biochim. Biophys. Acta | pmid:14757222 |
Mayatepek E et al. | Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. | 2004 | J. Lipid Res. | pmid:14754911 |
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Sloniewsky DE et al. | Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14578215 |
Capra V et al. | Involvement of prenylated proteins in calcium signaling induced by LTD4 in differentiated U937 cells. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518564 |
Thompson MD et al. | A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. | 2003 | Pharmacogenetics | pmid:14515063 |
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Bouchelouche K et al. | The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. | 2003 | J. Urol. | pmid:12853847 |
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