Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
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Grönroos E et al. | Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. | 1998 | Cell Calcium | pmid:9793684 |
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Allen S et al. | Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. | 1998 | Circulation | pmid:9641692 |
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Pedersen KE et al. | Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9152370 |
Beckh K et al. | Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide. | 1997 | Res Exp Med (Berl) | pmid:9406280 |
Cincu RN et al. | S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver. | 1997 | Hepatology | pmid:9252142 |
Goldhill J et al. | Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. | 1997 | Am. J. Physiol. | pmid:9176223 |
Sakurai S et al. | Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of [4-[1-(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives. | 1997 | Chem. Pharm. Bull. | pmid:9178522 |
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Sakurai S et al. | [Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of benzenesulfonamide derivatives]. | 1997 | Yakugaku Zasshi | pmid:9194397 |
O'Shaughnessy TC et al. | Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. | 1997 | Thorax | pmid:9227717 |
Meng XJ et al. | Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats. | 1997 | J. Clin. Invest. | pmid:9185515 |
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Wang Y et al. | Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores. | 1997 | J. Neurophysiol. | pmid:9065852 |
Dumitriu D et al. | Mechanism of action of leukotriene D4 on guinea pig tracheal smooth muscle cells: roles of Ca++ influx and intracellular Ca++ release. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9067324 |
Maehr H and Yang R | Structure optimization of a leukotriene D4 antagonist by combinatorial chemistry in solution. | 1997 | Bioorg. Med. Chem. | pmid:9113326 |
Joki S and Saano V | Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium. | 1997 | Clin. Exp. Pharmacol. Physiol. | pmid:9075591 |
Uno T et al. | Participation of leukotriene D4 and tumor necrosis factor on lipopolysaccharide-induced airway hyperresponsiveness in guinea pigs. | 1997 | Biol. Pharm. Bull. | pmid:9145204 |
Diamant Z et al. | The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105062 |
Pedersen S et al. | Leukotriene D4-induced Ca2+ mobilization in Ehrlich ascites tumor cells. | 1997 | J. Membr. Biol. | pmid:9002425 |
Ohd JF et al. | Leukotriene D4-induced signalling events in human epithelial cells: G alpha i3 activation and translocation. | 1997 | Adv. Exp. Med. Biol. | pmid:9561113 |
von Sprecher A et al. | CGP57698: a structurally simple, highly potent peptido-leukotriene (pLT) antagonist of the quinoline type. | 1997 | Adv. Exp. Med. Biol. | pmid:9561127 |
Honda I et al. | Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction. | 1997 | Fundam Clin Pharmacol | pmid:9243258 |
Kanli H and Terreros DA | Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus. | 1997 | Acta Physiol. Scand. | pmid:9246390 |
Wong WS et al. | Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336317 |
Cibulsky SM and Thompson DC | Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9399982 |
Muñoz NM et al. | Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105085 |