Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Linares Segovia B et al. | Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. | 2014 | BMC Pulm Med | pmid:25000942 |
Schwartz JI et al. | Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast. | 1993 | Br J Clin Pharmacol | pmid:12959296 |
Wensing G et al. | Pharmacodynamics and pharmacokinetics of BAY x 7195 aerosol, a new and selective receptor antagonist of cysteinyl-leukotrienes, in normal volunteers. | 1996 | Br J Clin Pharmacol | pmid:8864314 |
Wood-Baker R et al. | The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. | 1995 | Br J Clin Pharmacol | pmid:7742148 |
Mezhybovska M et al. | Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. | 2009 | Br. J. Cancer | pmid:19826421 |
Capra V et al. | Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. | 1998 | Br. J. Pharmacol. | pmid:9504401 |
Bäck M et al. | An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. | 2001 | Br. J. Pharmacol. | pmid:11487525 |
Liu YC et al. | Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. | 1998 | Br. J. Pharmacol. | pmid:9647482 |
Snetkov VA et al. | Mechanisms of leukotriene D4-induced constriction in human small bronchioles. | 2001 | Br. J. Pharmacol. | pmid:11350860 |
Shikada K and Tanaka S | Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. | 1993 | Br. J. Pharmacol. | pmid:8401920 |