Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kawashima Y et al. | Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. | 1998 | Pharm. Res. | pmid:9833999 |
Fujimura M et al. | A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs. | 1998 | Br. J. Pharmacol. | pmid:9831931 |
Kjellström S et al. | On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. | 1998 | J Chromatogr A | pmid:9818423 |
Arakida Y et al. | In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808690 |
Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
pmid:9797038 | ||||
Grönroos E et al. | Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. | 1998 | Cell Calcium | pmid:9793684 |
Tsang F et al. | Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. | 1998 | Br. J. Pharmacol. | pmid:9776345 |
Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
Kim N et al. | Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. | 1998 | Gastroenterology | pmid:9753495 |