LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Airway Obstruction D000402 13 associated lipids
Asbestosis D001195 8 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Asthma D001249 52 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Body Weight D001835 333 associated lipids
Brain Edema D001929 20 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Edema D004487 152 associated lipids
Enteritis D004751 8 associated lipids
Gastritis D005756 27 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Inflammation D007249 119 associated lipids
Influenza, Human D007251 11 associated lipids
Leukemia D007938 74 associated lipids
Neuralgia D009437 28 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Respirovirus Infections D010253 3 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Rhinitis D012220 10 associated lipids
Seizures D012640 87 associated lipids
Sneezing D012912 6 associated lipids
Stomach Ulcer D013276 75 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Nasal Obstruction D015508 4 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Carotid Stenosis D016893 15 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Endotoxemia D019446 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Ishinaga H et al. Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. 2005 Pharmacology pmid:15475658
Tokuyama K et al. Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. 2002 Pharmacology pmid:11893899
Xu L et al. Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings. 2010 Pharmazie pmid:21105577
Fukuishi N et al. Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. 2001 Phytomedicine pmid:11824521
Mizutani N et al. Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis. 2012 Phytother Res pmid:21698671
Smit NP et al. Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. 1995 Pigment Cell Res. pmid:7540755
Wienkötter N et al. The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance. 2008 Planta Med. pmid:18219598
Provost V et al. Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. 2012 PLoS ONE pmid:22952702
Lecca D et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. 2008 PLoS ONE pmid:18974869
Al-Husseini A et al. Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension. 2015 PLoS ONE pmid:25785937
Khaddaj-Mallat R et al. Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi. 2016 PLoS ONE pmid:27935998
Stelmach I et al. [The effect of inhaled heparin on post-leukotriene bronchoconstriction in children with bronchial asthma]. 2002 Pol. Merkur. Lekarski pmid:11995261
Maekawa A et al. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18931305
Habib GM et al. Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9560193
Maekawa A et al. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19561298
Maekawa A et al. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11226226
Young RN Discovery of montelukast: a once-a-day oral antagonist of leukotriene D4 for the treatment of chronic asthma. 2001 Prog Med Chem pmid:11774796
Rajah R et al. Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth. 1995 Prog. Growth Factor Res. pmid:8817670
Nakazawa T et al. Leukotriene D4-induced mucosal damage during long observation periods in vitro. 1994 Prostaglandins pmid:8066186
Tanaka H et al. The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. 1995 Nov-Dec Prostaglandins pmid:8838238