LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Airway Obstruction D000402 13 associated lipids
Asbestosis D001195 8 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Asthma D001249 52 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Body Weight D001835 333 associated lipids
Brain Edema D001929 20 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Edema D004487 152 associated lipids
Enteritis D004751 8 associated lipids
Gastritis D005756 27 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Inflammation D007249 119 associated lipids
Influenza, Human D007251 11 associated lipids
Leukemia D007938 74 associated lipids
Neuralgia D009437 28 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Respirovirus Infections D010253 3 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Rhinitis D012220 10 associated lipids
Seizures D012640 87 associated lipids
Sneezing D012912 6 associated lipids
Stomach Ulcer D013276 75 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Nasal Obstruction D015508 4 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Carotid Stenosis D016893 15 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Endotoxemia D019446 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Sparatore A and Sparatore F Preparation and pharmacological activities of 10-homolupinanoyl-2-R-phenothiazines. 1994 Farmaco pmid:7910463
Nishida T et al. Effects of leukotriene D4 on myocardial blood flow and high energy phosphate concentration in anesthetized dogs. 1994 Jpn. Circ. J. pmid:7967000
Hoheisel U and Mense S Leukotriene D4 depresses the mechanosensitivity of group III and IV muscle receptors in the rat. 1994 Neuroreport pmid:8025261
Hirata F et al. IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. 1994 Biochem. Biophys. Res. Commun. pmid:7945342
Kargman S et al. Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. 1994 Mol. Pharmacol. pmid:8190095
Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
Leier I et al. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. 1994 J. Biol. Chem. pmid:7961706
An S et al. Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4. 1994 Biochim. Biophys. Acta pmid:8054366
Tsopanoglou NE et al. Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. 1994 Eur. J. Pharmacol. pmid:7523148
Callaghan DH et al. Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. 1994 Pulm Pharmacol pmid:8003850
Kurosawa M et al. Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. 1994 Clin. Exp. Allergy pmid:7842366
Oliva D et al. Correlation between leukotriene D4-induced contraction and cytosolic calcium elevation: a quantitative and simultaneous evaluation in smooth muscle. 1994 J. Pharmacol. Exp. Ther. pmid:8301553
Howell RE et al. Leukotrienes mediate antigen-induced airway hyper-reactivity in guinea pigs. 1994 J. Pharmacol. Exp. Ther. pmid:8301576
Helvering LM et al. H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883. 1994 Carcinogenesis pmid:8313527
Inamura T et al. Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8171072
Herd CM et al. Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. 1994 Br. J. Pharmacol. pmid:8032653
Nathan RA et al. Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma. 1994 Chest pmid:8306751
Thioudellet C et al. Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. 1994 Eur. J. Biochem. pmid:7913033
Salari H et al. Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. 1994 J. Allergy Clin. Immunol. pmid:8182231
Kano M Calcium-induced long-lasting potentiation of GABAergic currents in cerebellar Purkinje cells. 1994 Jpn. J. Physiol. pmid:7752516