Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Claesson HE | On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19130894 |
Selg E et al. | Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19103301 |
Bengtsson AM et al. | Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18083053 |
Lötzer K et al. | 5-Lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991613 |
Abraham WM et al. | Effect of TYB-2285 on antigen-induced airway responses in sheep. | 1996 | Pulm Pharmacol | pmid:8843510 |
Joki S et al. | Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. | 1996 | Pulm Pharmacol | pmid:9160411 |
Callaghan DH et al. | Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. | 1994 | Pulm Pharmacol | pmid:8003850 |
Madsen F et al. | Challenge interval determines tachyphylaxis to aerosolized LTD4. | 1995 | Pulm Pharmacol | pmid:8819178 |
Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
Turner DJ et al. | Bradykinin-induced airway constriction in guinea-pigs: role of leukotriene D(4). | 2000 | Pulm Pharmacol Ther | pmid:10930357 |
Skogvall S et al. | Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. | 2007 | Pulm Pharmacol Ther | pmid:16731017 |
Pitt CM and Nally JE | Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? | 1999 | Pulm Pharmacol Ther | pmid:10208831 |
Skogvall S et al. | Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95. | 2008 | Pulm Pharmacol Ther | pmid:17374498 |
Yang XX et al. | The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. | 1999 | Pulm Pharmacol Ther | pmid:10545287 |
Schelfhout V et al. | The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. | 2008 | Pulm Pharmacol Ther | pmid:17611132 |
Hazel BA and Kalf GF | Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor. | 1996 | Recept Signal Transduct | pmid:8933618 |
Nagahisa A et al. | Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist. | 1993 | Regul. Pept. | pmid:7692561 |
Beckh K et al. | Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide. | 1997 | Res Exp Med (Berl) | pmid:9406280 |
McMillan JM and Jollow DJ | Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system. | 1995 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8564388 |
Guan WJ et al. | Impulse oscillometry for leukotriene D4 inhalation challenge in asthma. | 2013 | Respir Care | pmid:23716710 |