Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Takami M et al. | Possible role of thromboxane A2 in hyperresponsiveness of isolated rat lung tissue in a Sephadex-induced eosinophilia model. | 1995 | Int. Arch. Allergy Immunol. | pmid:7536504 |
Smit NP et al. | Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. | 1995 | Pigment Cell Res. | pmid:7540755 |
Hazel BA et al. | Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. | 1995 | Stem Cells | pmid:7542115 |
Cohen P et al. | Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis. | 1995 | Am. J. Physiol. | pmid:7544535 |
Meier HL et al. | Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. | 1995 | Int. J. Immunopharmacol. | pmid:7545649 |
Aida Y et al. | The antagonistic effects of khellactones on platelet-activating factor, histamine, and leukotriene D4. | 1995 | Chem. Pharm. Bull. | pmid:7553972 |
Kanwar S et al. | Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. | 1995 | Circ. Res. | pmid:7554141 |
Nasuhara Y et al. | [Acyclovir and guinea-pig airway smooth muscle]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:7563998 |
Tanaka T et al. | Effect of oxatomide on otitis media with effusion--an experimental study. | 1995 | Acta Otolaryngol. | pmid:7572131 |
Ganbo T et al. | Effect of ibudilast on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Arzneimittelforschung | pmid:7575753 |
Datta YH et al. | Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. | 1995 | Circulation | pmid:7586318 |
Nagase T et al. | In vitro airway and tissue response to antigen in sensitized rats. Role of serotonin and leukotriene D4. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7599867 |
Wettstein M et al. | Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state. | 1995 | Hepatology | pmid:7601416 |
Zhang MQ et al. | (Piperidinylalkoxy)chromones: novel antihistamines with additional antagonistic activity against leukotriene D4. | 1995 | J. Med. Chem. | pmid:7608912 |
Fiorucci S et al. | Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. | 1995 | Am. J. Physiol. | pmid:7611418 |
Goldhill JM et al. | Neural control of mouse small intestinal longitudinal muscle: interactions with inflammatory mediators. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7616450 |
Jones TR et al. | Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7621356 |
Grönroos E et al. | The regulation of leukotriene D4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation. | 1995 | Cell Calcium | pmid:7621531 |
Szarek JL and Valentovic MA | Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. | 1995 | Toxicology | pmid:7624868 |
Langer JC et al. | Mast cell mediators and peritoneal adhesion formation in the rat. | 1995 | J. Surg. Res. | pmid:7643592 |
Bochnowicz S and Underwood DC | Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7644563 |
Iwamoto I et al. | Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. | 1995 | Int. Arch. Allergy Immunol. | pmid:7647588 |
Kelefiotis D et al. | Eicosanoid-induced growth and signaling events in rat glomerular mesangial cells. | 1995 | Prostaglandins | pmid:7659782 |
Porreca E et al. | Cysteinyl-leukotriene D4 induced IL-1 beta expression and release in rat vascular smooth muscle cells. | 1995 | Atherosclerosis | pmid:7661877 |
Nagahisa A et al. | Antiinflammatory and analgesic activity of CP-96,345: an orally active non-peptide substance P receptor antagonist. | 1993 | Regul. Pept. | pmid:7692561 |
Powell WS et al. | Effects of dexamethasone on leukotriene synthesis and airway responses to antigen and leukotriene D4 in rats. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7697244 |
Tudhope SR et al. | BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. | 1994 | Eur. J. Pharmacol. | pmid:7698171 |
Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
Wasserman MA et al. | Synergism exhibited by LTD4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732851 |
Gronert K et al. | Endogenous sulfidopeptide leukotriene synthesis and 12-lipoxygenase activity in bullfrog (Rana catesbeiana) erythrocytes. | 1995 | Biochim. Biophys. Acta | pmid:7734448 |
Wood-Baker R et al. | The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. | 1995 | Br J Clin Pharmacol | pmid:7742148 |
Kano M | Calcium-induced long-lasting potentiation of GABAergic currents in cerebellar Purkinje cells. | 1994 | Jpn. J. Physiol. | pmid:7752516 |
Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
Donnelly AL et al. | The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7767514 |
Ramondt J et al. | Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. | 1995 | Prostaglandins | pmid:7792392 |
Gorenne I et al. | Antagonism of leukotriene responses in human airways by BAY x7195. | 1995 | Eur. J. Pharmacol. | pmid:7796856 |
Nabe T et al. | Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7824530 |
Sjölander A and Grönroos E | Leukotriene D4-induced signal transduction. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825836 |
Krell RD et al. | Preclinical exploration of the potential antiinflammatory properties of the peptide leukotriene antagonist ICI 204,219 (Accolate). | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825851 |
Kurosawa M et al. | Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. | 1994 | Clin. Exp. Allergy | pmid:7842366 |
Petric R and Ford-Hutchinson AW | Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. | 1994 | Kidney Int. | pmid:7853790 |
Patel JP et al. | Beneficial effects of combined thromboxane and leukotriene receptor antagonism in hemorrhagic shock. | 1995 | Crit. Care Med. | pmid:7867347 |
Wensing G et al. | Effect of BAY x 7195, an oral receptor antagonist of cysteinyl-leukotrienes, on leukotriene D4-induced bronchoconstriction in normal volunteers. | 1994 | Eur. J. Clin. Pharmacol. | pmid:7867675 |
Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
Tanaka T et al. | Protective effect of peptide leukotriene antagonist on renal failure induced by a tourniquet in rabbits. | 1995 | Forensic Sci. Int. | pmid:7875619 |
Sparatore A and Sparatore F | Preparation and pharmacological activities of 10-homolupinanoyl-2-R-phenothiazines. | 1994 | Farmaco | pmid:7910463 |
Thioudellet C et al. | Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. | 1994 | Eur. J. Biochem. | pmid:7913033 |
Hirata F et al. | IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7945342 |
Leier I et al. | The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. | 1994 | J. Biol. Chem. | pmid:7961706 |
Nishida T et al. | Effects of leukotriene D4 on myocardial blood flow and high energy phosphate concentration in anesthetized dogs. | 1994 | Jpn. Circ. J. | pmid:7967000 |
Furukawa K et al. | Simplified sulfidoleukotriene ELISA using LTD4-conjugated phosphatase for the study of allergen-induced leukotriene generation by isolated mononuclear cells and diluted whole blood. | 1994 May-Jun | J Investig Allergol Clin Immunol | pmid:7981880 |
Arakawa H et al. | Effect of maturation on airway plasma exudation induced by eicosanoids in guinea pig. | 1994 | Eur. J. Pharmacol. | pmid:7982451 |
Kelley M et al. | Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. | 1994 | Fundam Appl Toxicol | pmid:7982537 |
Callaghan DH et al. | Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. | 1994 | Pulm Pharmacol | pmid:8003850 |
Dandurand RJ et al. | In vitro allergic bronchoconstriction in the brown Norway rat. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8004305 |
Chan CC et al. | Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. | 1994 | Can. J. Physiol. Pharmacol. | pmid:8012892 |
Diamant Z et al. | Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. | 1994 | Eur. Respir. J. | pmid:8013602 |
Chan CC et al. | Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8014876 |
Hoheisel U and Mense S | Leukotriene D4 depresses the mechanosensitivity of group III and IV muscle receptors in the rat. | 1994 | Neuroreport | pmid:8025261 |
Herd CM et al. | Effect of a 5-lipoxygenase inhibitor and leukotriene antagonist (PF 5901) on antigen-induced airway responses in neonatally immunized rabbits. | 1994 | Br. J. Pharmacol. | pmid:8032653 |
Underwood DC et al. | Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8035322 |
Metters KM et al. | Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8035338 |
Diener M and Scharrer E | The effect of short-chain fatty acids on Cl- and K+ conductance in rat colonic crypts. | 1994 | Pflugers Arch. | pmid:8052516 |
An S et al. | Molecular cloning of sheep lung dipeptidase: a glycosyl phosphatidylinositol-anchored ectoenzyme that converts leukotriene D4 to leukotriene E4. | 1994 | Biochim. Biophys. Acta | pmid:8054366 |
Nakazawa T et al. | Leukotriene D4-induced mucosal damage during long observation periods in vitro. | 1994 | Prostaglandins | pmid:8066186 |
Tudorić N et al. | Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. | 1994 | Int. Arch. Allergy Immunol. | pmid:8111247 |
Ellis JL and Undem BJ | Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8111568 |
Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
Ramis I et al. | Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. | 1993 Nov-Dec | J Pharm Biomed Anal | pmid:8123725 |
Fauler J et al. | Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. | 1994 | Arthritis Rheum. | pmid:8129769 |
Welch MJ et al. | Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. | 1994 | Ann Allergy | pmid:8154635 |
Dahlén B et al. | The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics. | 1994 | Eur. Respir. J. | pmid:8162986 |
Inamura T et al. | Differential tissue expression of immunoreactive dehydropeptidase I, a peptidyl leukotriene metabolizing enzyme. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8171072 |
Mion F et al. | Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. | 1994 | Gut | pmid:8174986 |
Abela A and Daniel EE | Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. | 1994 | Am. J. Physiol. | pmid:8179018 |
Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
Ibe BO et al. | Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. | 1994 | Eur. J. Clin. Invest. | pmid:8187808 |
Kargman S et al. | Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. | 1994 | Mol. Pharmacol. | pmid:8190095 |
Han H et al. | Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction. | 1994 | Am. J. Physiol. | pmid:8203604 |
Hyun CS and Binder HJ | Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro. | 1993 | Am. J. Physiol. | pmid:8214069 |
Pawloski JR and Chapnick BM | Antagonism of LTD4-evoked relaxation in canine renal artery and vein. | 1993 | Am. J. Physiol. | pmid:8214135 |
Manning PJ et al. | Exercise-induced refractoriness in asthmatic subjects involves leukotriene and prostaglandin interdependent mechanisms. | 1993 | Am. Rev. Respir. Dis. | pmid:8214949 |
Arakawa H et al. | Leukotriene D4- and prostaglandin F2 alpha-induced airflow obstruction and airway plasma exudation in guinea-pig: role of thromboxane and its receptor. | 1993 | Br. J. Pharmacol. | pmid:8220872 |
Smith LJ et al. | Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. | 1993 | Clin. Pharmacol. Ther. | pmid:8222486 |
Yoshikawa S et al. | Modulation of acetylcholine release from the myenteric plexus of guinea-pig ileum by 5-lipoxygenase metabolites of arachidonic acid. | 1993 | Eur. J. Pharmacol. | pmid:8223906 |
Krauss AH and Woodward DF | Polymorphonuclear leukocyte infiltration into the subretinal choroid and optic nerve in response to leukotrienes. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:8258528 |
Mastrocola T et al. | Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux. | 1993 | J. Membr. Biol. | pmid:8271272 |
Spada CS et al. | Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro. | 1994 | J. Leukoc. Biol. | pmid:8301215 |
Krauss AH et al. | Determination of leukotriene effects on human neutrophil chemotaxis in vitro by differential assessment of cell motility and polarity. | 1994 | J. Leukoc. Biol. | pmid:8301217 |
Oliva D et al. | Correlation between leukotriene D4-induced contraction and cytosolic calcium elevation: a quantitative and simultaneous evaluation in smooth muscle. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301553 |
Howell RE et al. | Leukotrienes mediate antigen-induced airway hyper-reactivity in guinea pigs. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301576 |
Lee TH and Christie PE | Leukotrienes and aspirin induced asthma. | 1993 | Thorax | pmid:8303620 |
Dahlén B et al. | Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. | 1993 | Thorax | pmid:8303624 |
Nathan RA et al. | Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma. | 1994 | Chest | pmid:8306751 |
Helvering LM et al. | H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883. | 1994 | Carcinogenesis | pmid:8313527 |
Metters KM and Zamboni RJ | Photoaffinity labeling of the leukotriene D4 receptor in guinea pig lung. | 1993 | J. Biol. Chem. | pmid:8384212 |
Shikada K and Tanaka S | Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121. | 1993 | Br. J. Pharmacol. | pmid:8401920 |
Diener M and Scharrer E | The leukotriene D4 receptor blocker, SK&F 104353, inhibits volume regulation in isolated crypts from the rat distal colon. | 1993 | Eur. J. Pharmacol. | pmid:8405093 |
Conroy DM et al. | Relaxant effects of pituitary adenylate cyclase activating polypeptide (PACAP) on epithelium-intact and -denuded guinea-pig trachea: a comparison with vasoactive intestinal peptide (VIP). | 1995 | Neuropeptides | pmid:8538872 |
Howell RE et al. | Pulmonary pharmacology of WAY-126299A: a dual-acting 5-lipoxygenase inhibitor and leukotriene D4 antagonist. | 1995 | Inflamm. Res. | pmid:8548382 |