Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hougaard C et al. | K+ currents activated by leukotriene D4 or osmotic swelling in Ehrlich ascites tumour cells. | 2000 | Pflugers Arch. | pmid:10898529 |
Diener M and Scharrer E | The effect of short-chain fatty acids on Cl- and K+ conductance in rat colonic crypts. | 1994 | Pflugers Arch. | pmid:8052516 |
Kawashima Y et al. | Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. | 1998 | Pharm. Res. | pmid:9833999 |
Thompson MD et al. | A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. | 2003 | Pharmacogenetics | pmid:14515063 |
Pillai SG et al. | A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. | 2004 | Pharmacogenetics | pmid:15475736 |
Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
Lieber G et al. | Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat. | 2010 | Pharmacology | pmid:20453555 |
Ro JY et al. | The inhibitory mechanism of rebamipide on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions. | 2001 | Pharmacology | pmid:11598424 |
Ishinaga H et al. | Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. | 2005 | Pharmacology | pmid:15475658 |
Tokuyama K et al. | Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. | 2002 | Pharmacology | pmid:11893899 |