Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Vargaftig BB and Singer M | Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12794006 |
Carbajal V et al. | LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15377496 |
Yang G et al. | Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064240 |
Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
Liu P et al. | Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12531730 |
Talukder JR et al. | Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18436626 |
Goldhill J et al. | Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. | 1997 | Am. J. Physiol. | pmid:9176223 |
Olszewski MA et al. | Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. | 1999 | Am. J. Physiol. | pmid:10070118 |
Sato E et al. | Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. | 1998 | Am. J. Physiol. | pmid:9609736 |
Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |