Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Francis HP et al. | The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. | 1998 | Br. J. Pharmacol. | pmid:9484852 |
Hoshino M et al. | Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. | 1998 | J. Biol. Chem. | pmid:9478929 |
Fujita M et al. | Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469641 |
Gorenne I et al. | Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9454796 |
Beckh K et al. | Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide. | 1997 | Res Exp Med (Berl) | pmid:9406280 |
Cibulsky SM and Thompson DC | Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9399982 |
Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
Beckh K et al. | Effects of nitric oxide on leukotriene D4 decreased bile secretion in the perfused rat liver. | 1997 | Life Sci. | pmid:9364199 |
Wong WS et al. | Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336317 |
Spector SL | Leukotriene activity modulation in asthma. | 1997 | Drugs | pmid:9279501 |