LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Airway Obstruction D000402 13 associated lipids
Asbestosis D001195 8 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Asthma D001249 52 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Body Weight D001835 333 associated lipids
Brain Edema D001929 20 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Edema D004487 152 associated lipids
Enteritis D004751 8 associated lipids
Gastritis D005756 27 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Inflammation D007249 119 associated lipids
Influenza, Human D007251 11 associated lipids
Leukemia D007938 74 associated lipids
Neuralgia D009437 28 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Respirovirus Infections D010253 3 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Rhinitis D012220 10 associated lipids
Seizures D012640 87 associated lipids
Sneezing D012912 6 associated lipids
Stomach Ulcer D013276 75 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Nasal Obstruction D015508 4 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Carotid Stenosis D016893 15 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Endotoxemia D019446 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Georgitis JW et al. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. 1995 Int. Arch. Allergy Immunol. pmid:7719157
Szarek JL and Valentovic MA Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. 1995 Toxicology pmid:7624868
Ganbo T et al. Effect of ibudilast on ciliary activity of human paranasal sinus mucosa in vitro. 1995 Arzneimittelforschung pmid:7575753
Aida Y et al. The antagonistic effects of khellactones on platelet-activating factor, histamine, and leukotriene D4. 1995 Chem. Pharm. Bull. pmid:7553972
Nagase T et al. In vitro airway and tissue response to antigen in sensitized rats. Role of serotonin and leukotriene D4. 1995 Am. J. Respir. Crit. Care Med. pmid:7599867
Hazel BA et al. Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. 1995 Stem Cells pmid:7542115
Cohen P et al. Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis. 1995 Am. J. Physiol. pmid:7544535
Zhang MQ et al. (Piperidinylalkoxy)chromones: novel antihistamines with additional antagonistic activity against leukotriene D4. 1995 J. Med. Chem. pmid:7608912
Nasuhara Y et al. [Acyclovir and guinea-pig airway smooth muscle]. 1995 Nihon Kyobu Shikkan Gakkai Zasshi pmid:7563998
Iwamoto I et al. Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. 1995 Int. Arch. Allergy Immunol. pmid:7647588
Donnelly AL et al. The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. 1995 Am. J. Respir. Crit. Care Med. pmid:7767514
Herron DK et al. Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. 1995 J Mol Graph pmid:8820302
Ganbo T et al. The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. 1995 Rhinology pmid:8919211
Bonnefoi MS et al. Subchronic toxicity studies with the leukotriene D4 antagonist RG 12525. 1995 Fundam Appl Toxicol pmid:8566477
Rajah R et al. Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth. 1995 Prog. Growth Factor Res. pmid:8817670
Madsen F et al. Challenge interval determines tachyphylaxis to aerosolized LTD4. 1995 Pulm Pharmacol pmid:8819178
Tanaka H et al. The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. 1995 Nov-Dec Prostaglandins pmid:8838238
Datta HK et al. Parathyroid hormone induces superoxide anion burst in the osteoclast: evidence for the direct instantaneous activation of the osteoclast by the hormone. 1996 J. Endocrinol. pmid:8708538
Underwood DC et al. Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. 1996 Am. J. Respir. Crit. Care Med. pmid:8887574
Aizawa H et al. Thromboxane A2 antagonist inhibits leukotriene D4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014223