LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Endotoxemia D019446 27 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carotid Stenosis D016893 15 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Nasal Obstruction D015508 4 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Stomach Ulcer D013276 75 associated lipids
Sneezing D012912 6 associated lipids
Seizures D012640 87 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Respirovirus Infections D010253 3 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Neuralgia D009437 28 associated lipids
Leukemia D007938 74 associated lipids
Influenza, Human D007251 11 associated lipids
Inflammation D007249 119 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glomerulonephritis D005921 35 associated lipids
Glioma D005910 112 associated lipids
Gastritis D005756 27 associated lipids
Enteritis D004751 8 associated lipids
Edema D004487 152 associated lipids
Cough D003371 19 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Brain Edema D001929 20 associated lipids
Body Weight D001835 333 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Asthma D001249 52 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Asbestosis D001195 8 associated lipids
Airway Obstruction D000402 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Mazzetti L et al. The ACh-induced contraction in rat aortas is mediated by the Cys Lt1 receptor via intracellular calcium mobilization in smooth muscle cells. 2003 Br. J. Pharmacol. pmid:12598425
Wunder F et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. 2010 Br. J. Pharmacol. pmid:20423349
Ishimura M et al. Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs. 2008 Br. J. Pharmacol. pmid:18037905
Ortiz JL et al. Leukotriene receptors on human pulmonary vascular endothelium. 1995 Br. J. Pharmacol. pmid:8564195
Sermasi E et al. Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience. 1999 Brain Res. Dev. Brain Res. pmid:10064875
Jones TR et al. Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. 1995 Can. J. Physiol. Pharmacol. pmid:7621356
Yamashita T and Kokubun S Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. 1999 Can. J. Physiol. Pharmacol. pmid:10588484
Nagase T and Ludwig MS Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. 1998 Can. J. Physiol. Pharmacol. pmid:9635157
Chan CC et al. Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. 1994 Can. J. Physiol. Pharmacol. pmid:8012892
Nagayama S et al. Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. 1998 Cancer Lett. pmid:9751271
Nielsen CK et al. A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. 2005 Cancer Res. pmid:15705869
Helvering LM et al. H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883. 1994 Carcinogenesis pmid:8313527
Parhamifar L et al. Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. 2005 Carcinogenesis pmid:15975962
Zhou G et al. Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. 2010 Cardiology pmid:20234134
Finkensieper A et al. The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. 2010 Cardiovasc. Res. pmid:19965960
Chen C et al. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. 1995 Cell pmid:8548809
Robbiani DF et al. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. 2000 Cell pmid:11114332
Fukai F et al. Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. 1996 Cell Biol. Int. pmid:8858827
Gorenne I et al. Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation. 1996 Cell Biol. Toxicol. pmid:9034615
Grönroos E et al. Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. 1998 Cell Calcium pmid:9793684