Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mazzetti L et al. | The ACh-induced contraction in rat aortas is mediated by the Cys Lt1 receptor via intracellular calcium mobilization in smooth muscle cells. | 2003 | Br. J. Pharmacol. | pmid:12598425 |
Wunder F et al. | Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. | 2010 | Br. J. Pharmacol. | pmid:20423349 |
Ishimura M et al. | Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs. | 2008 | Br. J. Pharmacol. | pmid:18037905 |
Ortiz JL et al. | Leukotriene receptors on human pulmonary vascular endothelium. | 1995 | Br. J. Pharmacol. | pmid:8564195 |
Sermasi E et al. | Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience. | 1999 | Brain Res. Dev. Brain Res. | pmid:10064875 |
Jones TR et al. | Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7621356 |
Yamashita T and Kokubun S | Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588484 |
Nagase T and Ludwig MS | Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. | 1998 | Can. J. Physiol. Pharmacol. | pmid:9635157 |
Chan CC et al. | Evaluation of bronchoconstriction induced by neurokinins and its inhibition by selective nonpeptide antagonists in conscious guinea pigs, using a double-chamber plethysmograph technique. | 1994 | Can. J. Physiol. Pharmacol. | pmid:8012892 |
Nagayama S et al. | Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. | 1998 | Cancer Lett. | pmid:9751271 |
Nielsen CK et al. | A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. | 2005 | Cancer Res. | pmid:15705869 |
Helvering LM et al. | H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883. | 1994 | Carcinogenesis | pmid:8313527 |
Parhamifar L et al. | Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells. | 2005 | Carcinogenesis | pmid:15975962 |
Zhou G et al. | Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. | 2010 | Cardiology | pmid:20234134 |
Finkensieper A et al. | The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. | 2010 | Cardiovasc. Res. | pmid:19965960 |
Chen C et al. | Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. | 1995 | Cell | pmid:8548809 |
Robbiani DF et al. | The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. | 2000 | Cell | pmid:11114332 |
Fukai F et al. | Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. | 1996 | Cell Biol. Int. | pmid:8858827 |
Gorenne I et al. | Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation. | 1996 | Cell Biol. Toxicol. | pmid:9034615 |
Grönroos E et al. | Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. | 1998 | Cell Calcium | pmid:9793684 |