Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yamaya M et al. | Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. | 1998 | Respir Physiol | pmid:9496476 |
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Ravasi S et al. | CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. | 2006 | Respir. Res. | pmid:16553950 |
Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
Shirasaki H et al. | The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. | 1998 | Rhinology | pmid:9695159 |
Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
Reims A et al. | Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. | 2005 | Scand. J. Gastroenterol. | pmid:15764146 |
Julius P et al. | sCD14 in bronchoalveolar lavage 18, 42 and 162 hours after segmental allergen provocation. | 2010 | Scand. J. Immunol. | pmid:20384875 |
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Hazel BA et al. | Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor. | 1995 | Stem Cells | pmid:7542115 |
Sampson SE et al. | Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. | 1997 | Thorax | pmid:9227716 |
O'Shaughnessy TC et al. | Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. | 1997 | Thorax | pmid:9227717 |
Lee TH and Christie PE | Leukotrienes and aspirin induced asthma. | 1993 | Thorax | pmid:8303620 |
Dahlén B et al. | Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. | 1993 | Thorax | pmid:8303624 |
Ketchell RI et al. | Contrasting effects of allergen challenge on airway responsiveness to cysteinyl leukotriene D(4) and methacholine in mild asthma. | 2002 | Thorax | pmid:12096198 |
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Porreca E et al. | Cysteinyl leukotriene D4 induced vascular smooth muscle cell proliferation: a possible role in myointimal hyperplasia. | 1996 | Thromb. Haemost. | pmid:8819260 |
Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
Lee SJ et al. | 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19837106 |
Sharkey LC et al. | Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23993975 |
Xiao J et al. | Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. | 2015 | Toxicol. Sci. | pmid:25432964 |
Szarek JL and Valentovic MA | Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. | 1995 | Toxicology | pmid:7624868 |
Zhou Y et al. | Circulating LTD4 in patients with hepatocellular carcinoma. | 2011 | Tumour Biol. | pmid:20820981 |
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Bouchelouche K et al. | Calcium signaling in cultured human detrusor smooth muscle cells from patients with interstitial cystitis. | 2001 | Urology | pmid:11378073 |
Bouchelouche K et al. | Cysteinyl-leukotriene D(4) receptors in smooth muscle cells. | 2001 | Urology | pmid:11378074 |
Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
Sakurai S et al. | [Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of benzenesulfonamide derivatives]. | 1997 | Yakugaku Zasshi | pmid:9194397 |
Mizutani N | [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. | 2003 | Yakugaku Zasshi | pmid:12607939 |
Zhang Z et al. | [Leukotriene D4 activates BV2 microglia in vitro]. | 2013 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:23801612 |
Cai BL et al. | [Effects of agonist and antagonist of cysteinyl leukotriene receptors on differentiation of rat glioma C6 cells]. | 2011 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:21488208 |
Cai BL et al. | [Method for screening cysteinyl leukotriene receptor 2 antagonists and preliminary screening of compounds]. | 2009 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20014485 |
Hu X et al. | [Effects of cysteinyl receptor agonist and antagonists on rat primary cortical neurons]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17443896 |
Peng F et al. | [Cysteinyl leukotriene receptor 1 antagonist pranlukast modulates differentiation of SK-N-SH cells]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17443897 |
Li R et al. | [Analysis of the nasopharyngeal aspirates in children with different severities of bronchiolitis]. | 2010 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:20497653 |
Yang HS et al. | [Effects of leukotriene receptor antagonists on vascular endothelial growth factor and its receptors in a sensitized rat model]. | 2009 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:19575935 |