Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Brochu-Bourque A et al. | Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor. | 2011 | J. Pharmacol. Exp. Ther. | pmid:20966037 |
Ni NC et al. | A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21903747 |
Dartt DA et al. | Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | 2011 | J. Immunol. | pmid:21357260 |
Chen LY et al. | Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes. | 2011 | Allergy | pmid:21605126 |
Ahmed T et al. | Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence. | 2012 | Respir. Res. | pmid:22269021 |
Provost V et al. | Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. | 2012 | PLoS ONE | pmid:22952702 |
Dahlén B et al. | Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22457014 |
Guan W et al. | Leukotriene D4 bronchial provocation test: methodology and diagnostic value. | 2012 | Curr Med Res Opin | pmid:22435894 |
Forsell PK et al. | Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. | 2012 | Lipids | pmid:22684912 |
Parmentier CN et al. | Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1. | 2012 | J. Allergy Clin. Immunol. | pmid:22391114 |
Rehn M and Diener M | Cysteinyl leukotrienes mediate the response of submucosal ganglia from rat colon to bradykinin. | 2012 | Eur. J. Pharmacol. | pmid:22366210 |
Huang XQ et al. | Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1. | 2012 | J Neuroinflammation | pmid:22734808 |
Dannull J et al. | Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. | 2012 | Blood | pmid:22323449 |
Mizutani N et al. | Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis. | 2012 | Phytother Res | pmid:21698671 |
Pelclová D et al. | Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. | 2012 | Ind Health | pmid:22785421 |
Matsumoto H et al. | Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells. | 2012 | Cytokine | pmid:22078634 |
Drost AC et al. | The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia. | 2012 | Leuk. Lymphoma | pmid:21936770 |
Tang SS et al. | Leukotriene D4 induces cognitive impairment through enhancement of CysLT₠R-mediated amyloid-β generation in mice. | 2013 | Neuropharmacology | pmid:22982445 |
Jørgensen ST et al. | Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization. | 2013 | Cell. Physiol. Biochem. | pmid:23485744 |
Germain AR et al. | Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23403082 |