LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Endotoxemia D019446 27 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carotid Stenosis D016893 15 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Nasal Obstruction D015508 4 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Stomach Ulcer D013276 75 associated lipids
Sneezing D012912 6 associated lipids
Seizures D012640 87 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Respirovirus Infections D010253 3 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Neuralgia D009437 28 associated lipids
Leukemia D007938 74 associated lipids
Influenza, Human D007251 11 associated lipids
Inflammation D007249 119 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glomerulonephritis D005921 35 associated lipids
Glioma D005910 112 associated lipids
Gastritis D005756 27 associated lipids
Enteritis D004751 8 associated lipids
Edema D004487 152 associated lipids
Cough D003371 19 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Brain Edema D001929 20 associated lipids
Body Weight D001835 333 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Asthma D001249 52 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
Asbestosis D001195 8 associated lipids
Airway Obstruction D000402 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Javed NH et al. Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs. 1994 Agents Actions pmid:7521569
Dandurand RJ et al. In vitro allergic bronchoconstriction in the brown Norway rat. 1994 Am. J. Respir. Crit. Care Med. pmid:8004305
Underwood DC et al. Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. 1994 J. Pharmacol. Exp. Ther. pmid:8035322
Mion F et al. Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. 1994 Gut pmid:8174986
Salari H et al. Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. 1994 J. Allergy Clin. Immunol. pmid:8182231
Sanz ML et al. Modulation of beta 2-adrenoceptors in human lymphocytes by in vitro stimulation with mediators. 1994 May-Jun J Investig Allergol Clin Immunol pmid:7526943
Furukawa K et al. Simplified sulfidoleukotriene ELISA using LTD4-conjugated phosphatase for the study of allergen-induced leukotriene generation by isolated mononuclear cells and diluted whole blood. 1994 May-Jun J Investig Allergol Clin Immunol pmid:7981880
Goldhill JM et al. Neural control of mouse small intestinal longitudinal muscle: interactions with inflammatory mediators. 1995 J. Pharmacol. Exp. Ther. pmid:7616450
Jones TR et al. Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist. 1995 Can. J. Physiol. Pharmacol. pmid:7621356
Grönroos E et al. The regulation of leukotriene D4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation. 1995 Cell Calcium pmid:7621531
Tanaka T et al. Effect of oxatomide on otitis media with effusion--an experimental study. 1995 Acta Otolaryngol. pmid:7572131
Ganbo T et al. Effect of ibudilast on ciliary activity of human paranasal sinus mucosa in vitro. 1995 Arzneimittelforschung pmid:7575753
Donnelly AL et al. The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. 1995 Am. J. Respir. Crit. Care Med. pmid:7767514
Bochnowicz S and Underwood DC Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7644563
Weiss SR et al. Quenching: inhibition of development and expression of amygdala kindled seizures with low frequency stimulation. 1995 Neuroreport pmid:8595196
Tasaka K et al. Effect of loratadine on immediate and delayed type hypersensitivity reactions. 1995 Arzneimittelforschung pmid:8573225
Tudoric N et al. Effects of halothane and isoflurane on antigen- and leukotriene-D4-induced constriction of guinea pig trachea. 1995 Acta Anaesthesiol Scand pmid:8607320
Ortiz JL et al. Leukotriene receptors on human pulmonary vascular endothelium. 1995 Br. J. Pharmacol. pmid:8564195
McMillan JM and Jollow DJ Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system. 1995 Res. Commun. Mol. Pathol. Pharmacol. pmid:8564388
Bonnefoi MS et al. Subchronic toxicity studies with the leukotriene D4 antagonist RG 12525. 1995 Fundam Appl Toxicol pmid:8566477