Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Chen C et al. | Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. | 1995 | Cell | pmid:8548809 |
Ortiz JL et al. | Leukotriene receptors on human pulmonary vascular endothelium. | 1995 | Br. J. Pharmacol. | pmid:8564195 |
McMillan JM and Jollow DJ | Macrophage enhancement of galactosamine hepatotoxicity using a rat hepatocyte culture system. | 1995 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8564388 |
Bonnefoi MS et al. | Subchronic toxicity studies with the leukotriene D4 antagonist RG 12525. | 1995 | Fundam Appl Toxicol | pmid:8566477 |
Tasaka K et al. | Effect of loratadine on immediate and delayed type hypersensitivity reactions. | 1995 | Arzneimittelforschung | pmid:8573225 |
Weiss SR et al. | Quenching: inhibition of development and expression of amygdala kindled seizures with low frequency stimulation. | 1995 | Neuroreport | pmid:8595196 |
Tudoric N et al. | Effects of halothane and isoflurane on antigen- and leukotriene-D4-induced constriction of guinea pig trachea. | 1995 | Acta Anaesthesiol Scand | pmid:8607320 |
Heimbürger M and Palmblad JE | Effects of leukotriene C4 and D4, histamine and bradykinin on cytosolic calcium concentrations and adhesiveness of endothelial cells and neutrophils. | 1996 | Clin. Exp. Immunol. | pmid:8608646 |
Grönroos E et al. | Leukotriene D4-induced mobilization of intracellular Ca2+ in epithelial cells is critically dependent on activation of the small GTP-binding protein Rho. | 1996 | Biochem. J. | pmid:8645211 |
Jorgensen NK et al. | Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. | 1996 | J. Membr. Biol. | pmid:8661498 |
Dudek SM and Friedlander MJ | Developmental down-regulation of LTD in cortical layer IV and its independence of modulation by inhibition. | 1996 | Neuron | pmid:8663986 |
Sakurai S et al. | Synthesis and thromboxane A2 antagonistic activity of [[1-aryl(or benzyl)-1-(benzenesulfonamido)methyl]phenyl]alkanoic acid derivatives. | 1996 | Chem. Pharm. Bull. | pmid:8681409 |
Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
Funayama T et al. | Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8703483 |
Datta HK et al. | Parathyroid hormone induces superoxide anion burst in the osteoclast: evidence for the direct instantaneous activation of the osteoclast by the hormone. | 1996 | J. Endocrinol. | pmid:8708538 |
Konno A et al. | Role of substance P in the vascular response of nasal mucosa in nasal allergy. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8712637 |
Ishikawa J et al. | Involvement of endogenous tachykinins in LTD4-induced airway responses. | 1996 | Eur. Respir. J. | pmid:8730008 |
Carlton RA et al. | Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525. | 1996 | J Pharm Sci | pmid:8742935 |
Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |
Shikada K and Tanaka S | Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea. | 1996 | Prostaglandins | pmid:8792445 |
Adolfsson JL et al. | Leukotriene D4-induced activation and translocation of the G-protein alpha i3-subunit in human epithelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806649 |
Rajah R et al. | Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth. | 1995 | Prog. Growth Factor Res. | pmid:8817670 |
Madsen F et al. | Challenge interval determines tachyphylaxis to aerosolized LTD4. | 1995 | Pulm Pharmacol | pmid:8819178 |
Porreca E et al. | Cysteinyl leukotriene D4 induced vascular smooth muscle cell proliferation: a possible role in myointimal hyperplasia. | 1996 | Thromb. Haemost. | pmid:8819260 |
Tominaga M et al. | ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819486 |
Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
Hendeles L and Marshik PL | Zileuton: a new therapy for asthma or just the first of a new class of drugs. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826576 |
Reiss TF et al. | Effects of montelukast (MK-0476), a new potent cysteinyl leukotriene (LTD4) receptor antagonist, in patients with chronic asthma. | 1996 | J. Allergy Clin. Immunol. | pmid:8828530 |
Patry C et al. | Leukotriene receptors in HL-60 cells differentiated into eosinophils, monocytes and neutrophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8832765 |
Tanaka H et al. | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. | 1995 Nov-Dec | Prostaglandins | pmid:8838238 |
Ochsner M | The action of the peptidoleukotriene LTD4 on intracellular calcium in rat mesangial cells. | 1996 | Experientia | pmid:8841513 |
Abraham WM et al. | Effect of TYB-2285 on antigen-induced airway responses in sheep. | 1996 | Pulm Pharmacol | pmid:8843510 |
Fukai F et al. | Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. | 1996 | Cell Biol. Int. | pmid:8858827 |
Wensing G et al. | Pharmacodynamics and pharmacokinetics of BAY x 7195 aerosol, a new and selective receptor antagonist of cysteinyl-leukotrienes, in normal volunteers. | 1996 | Br J Clin Pharmacol | pmid:8864314 |
Tai S et al. | Effect of leukotriene D4 on tracheal mucociliary transport velocity in quails. | 1996 | Jpn. J. Pharmacol. | pmid:8866758 |
Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
Underwood DC et al. | Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887574 |
Omori C et al. | Eicosanoids modulate hyperpnea-induced bronchoconstriction in canine peripheral airways. | 1996 | J. Appl. Physiol. | pmid:8889761 |
Chong K et al. | Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis. | 1996 | J Pharm Biomed Anal | pmid:8895082 |
Hisamatsu K et al. | Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. | 1996 | Prostaglandins | pmid:8900445 |
Martin CA et al. | In vitro pharmacological effects of S 12370 (2-[4-benzhydryloxypiperidinoethyl]isoxindole; an antibronchoconstrictor agent) in normal and sensitized tissue. | 1996 | Fundam Clin Pharmacol | pmid:8902549 |
Kaminuma O et al. | Inhibitory effect of a novel phosphodiesterase IV inhibitor, T-440, on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo. | 1996 | Jpn. J. Pharmacol. | pmid:8902593 |
Gyömber E et al. | Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. | 1996 | J. Gastroenterol. Hepatol. | pmid:8912128 |
Nagase T et al. | Roles of calcitonin gene-related peptide (CGRP) in hyperpnea-induced constriction in guinea pigs. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8912779 |
Kang BC et al. | Experimental asthma developed by room air contamination with cockroach allergen. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917126 |
Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
Nagase T et al. | Airway and tissue behavior during early response in sensitized rats: role of 5-HT and LTD4. | 1996 | J. Appl. Physiol. | pmid:8929602 |
Hazel BA and Kalf GF | Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor. | 1996 | Recept Signal Transduct | pmid:8933618 |
Nakamura S et al. | Effects of 1-[3-(4-benzhydryl-1-piperazinyl)propyl]-3- (1H-imidazol-1-ylmethyl)-1H-indole-6-carboxylic acid with thromboxane A2 synthetase inhibitory and H1-blocking activities on anaphylactic bronchospasm. | 1996 | Arzneimittelforschung | pmid:8955866 |
Bäck M et al. | The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. | 1996 | Eur. J. Pharmacol. | pmid:8982726 |
Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
Rajah R et al. | Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. | 1996 | Am. J. Physiol. | pmid:8997273 |
Pedersen S et al. | Leukotriene D4-induced Ca2+ mobilization in Ehrlich ascites tumor cells. | 1997 | J. Membr. Biol. | pmid:9002425 |
Brocks DR et al. | The single and multiple dose pharmacokinetics of pranlukast in healthy volunteers. | 1996 | Eur. J. Clin. Pharmacol. | pmid:9010703 |
Aizawa H et al. | Thromboxane A2 antagonist inhibits leukotriene D4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014223 |
Gissurarson SR et al. | Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023290 |
Kubes P | Nitric oxide and microvascular permeability: a continuing dilemma. | 1997 | Eur. Respir. J. | pmid:9032483 |
Kageyama N et al. | Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators. | 1997 | Eur. Respir. J. | pmid:9032485 |
Gorenne I et al. | Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation. | 1996 | Cell Biol. Toxicol. | pmid:9034615 |
Tvaermose-Nielsen O et al. | Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. | 1997 | Bioorg. Med. Chem. | pmid:9061206 |
Wang Y et al. | Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores. | 1997 | J. Neurophysiol. | pmid:9065852 |
Dumitriu D et al. | Mechanism of action of leukotriene D4 on guinea pig tracheal smooth muscle cells: roles of Ca++ influx and intracellular Ca++ release. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9067324 |
Joki S and Saano V | Influence of ageing on ciliary beat frequency and on ciliary response to leukotriene D4 in guinea-pig tracheal epithelium. | 1997 | Clin. Exp. Pharmacol. Physiol. | pmid:9075591 |
Zhang MQ and Timmerman H | Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study. | 1997 | Inflamm. Res. | pmid:9098782 |
Diamant Z et al. | The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105062 |
Muñoz NM et al. | Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9105085 |
Maehr H and Yang R | Structure optimization of a leukotriene D4 antagonist by combinatorial chemistry in solution. | 1997 | Bioorg. Med. Chem. | pmid:9113326 |
Hazel BA et al. | Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone. | 1996 | Environ. Health Perspect. | pmid:9118902 |
Uno T et al. | Participation of leukotriene D4 and tumor necrosis factor on lipopolysaccharide-induced airway hyperresponsiveness in guinea pigs. | 1997 | Biol. Pharm. Bull. | pmid:9145204 |
Pedersen KE et al. | Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9152370 |
Joki S et al. | Effect of leukotriene D4 on ciliary activity in human, guinea-pig and rat respiratory mucosa. | 1996 | Pulm Pharmacol | pmid:9160411 |
Goldhill J et al. | Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. | 1997 | Am. J. Physiol. | pmid:9176223 |
Sakurai S et al. | Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of [4-[1-(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives. | 1997 | Chem. Pharm. Bull. | pmid:9178522 |
Meng XJ et al. | Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats. | 1997 | J. Clin. Invest. | pmid:9185515 |
Sakurai S et al. | [Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of benzenesulfonamide derivatives]. | 1997 | Yakugaku Zasshi | pmid:9194397 |
Sampson SE et al. | Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. | 1997 | Thorax | pmid:9227716 |
O'Shaughnessy TC et al. | Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. | 1997 | Thorax | pmid:9227717 |
Honda I et al. | Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction. | 1997 | Fundam Clin Pharmacol | pmid:9243258 |
Kanli H and Terreros DA | Transepithelial transport and cell volume control in proximal renal tubules from the teleost Carassius auratus. | 1997 | Acta Physiol. Scand. | pmid:9246390 |
Cincu RN et al. | S-adenosyl-L-methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: a study with isolated and perfused rat liver. | 1997 | Hepatology | pmid:9252142 |
Spector SL | Leukotriene activity modulation in asthma. | 1997 | Drugs | pmid:9279501 |
Wong WS et al. | Effects of tyrosine kinase inhibitors on antigen challenge of guinea pig lung in vitro. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336317 |
Beckh K et al. | Effects of nitric oxide on leukotriene D4 decreased bile secretion in the perfused rat liver. | 1997 | Life Sci. | pmid:9364199 |
Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
Cibulsky SM and Thompson DC | Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9399982 |
Beckh K et al. | Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide. | 1997 | Res Exp Med (Berl) | pmid:9406280 |
Gorenne I et al. | Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9454796 |
Fujita M et al. | Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469641 |
Hoshino M et al. | Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. | 1998 | J. Biol. Chem. | pmid:9478929 |
Francis HP et al. | The effects of a novel sulphidopeptide leukotriene antagonist, BAY x7195, against elicited bronchoconstriction in the anaesthetized guinea-pig. | 1998 | Br. J. Pharmacol. | pmid:9484852 |
Yamaya M et al. | Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. | 1998 | Respir Physiol | pmid:9496476 |
Basavappa S et al. | Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. | 1998 | J. Neurophysiol. | pmid:9497423 |
Capra V et al. | Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. | 1998 | Br. J. Pharmacol. | pmid:9504401 |
Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
Capra V et al. | Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. | 1998 | Mol. Pharmacol. | pmid:9547367 |
Przylipiak A et al. | Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. | 1998 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:9550202 |
Zwaagstra ME et al. | Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. | 1998 | J. Med. Chem. | pmid:9554876 |
Cyrus CB et al. | Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. | 1998 | Otolaryngol Head Neck Surg | pmid:9560097 |
Habib GM et al. | Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9560193 |