Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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McMahon B et al. | Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. | 2002 | FASEB J. | pmid:12223454 |
Thodeti CK and Sjölander A | Leukotriene D4-induced calcium signaling in human intestinal epithelial cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664584 |
Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
Ohshima N et al. | A functional study on CysLT(1) receptors in human eosinophils. | 2002 | Int. Arch. Allergy Immunol. | pmid:12373000 |
Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |
Maekawa A et al. | Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. | 2002 | J. Biol. Chem. | pmid:11932261 |
Tada N et al. | Experimental otitis media with effusion induced by leukotriene D4. | 2002 | Auris Nasus Larynx | pmid:11893446 |
Li X and Weinman SA | Mrp2 modulates the activity of chloride channels in isolated hepatocytes. | 2002 | Hepatology | pmid:12085350 |
Bandeira-Melo C et al. | Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. | 2002 | J. Exp. Med. | pmid:12235216 |
Shahbazian A et al. | Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. | 2002 | Br. J. Pharmacol. | pmid:12429577 |
Walch L et al. | Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. | 2002 | Br. J. Pharmacol. | pmid:12466244 |
Neu IS et al. | Leukotrienes in patients with clinically active multiple sclerosis. | 2002 | Acta Neurol. Scand. | pmid:11903112 |
Sakata K and Bäck M | Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma. | 2002 | Eur. J. Pharmacol. | pmid:11834255 |
Obase Y et al. | Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. | 2002 | Chest | pmid:11796443 |
Braccioni F et al. | The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. | 2002 | J. Allergy Clin. Immunol. | pmid:12110827 |
Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |
Tokuyama K et al. | Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. | 2002 | Pharmacology | pmid:11893899 |
Lee KH et al. | Increased expression of endothelial cell adhesion molecules due to mediator release from human foreskin mast cells stimulated by autoantibodies in chronic urticaria sera. | 2002 | J. Invest. Dermatol. | pmid:11918713 |
Li PC et al. | Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. | 2002 | J. Cell. Physiol. | pmid:12115725 |
Massoumi R et al. | Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta. | 2002 | J. Cell. Sci. | pmid:12154081 |
Han B et al. | Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. | 2002 | Am. J. Pathol. | pmid:12163373 |
Paruchuri S et al. | Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells. | 2002 | J. Cell. Sci. | pmid:11956320 |
Stelmach I et al. | [The effect of inhaled heparin on post-leukotriene bronchoconstriction in children with bronchial asthma]. | 2002 | Pol. Merkur. Lekarski | pmid:11995261 |
Allakhverdi Z et al. | Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11934731 |
Lavoie JP et al. | Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. | 2002 | Am. J. Vet. Res. | pmid:11939323 |
Nagata M et al. | Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. | 2002 | J. Allergy Clin. Immunol. | pmid:11941318 |
Evans JF | Cysteinyl leukotriene receptors. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432945 |
Ketchell RI et al. | Contrasting effects of allergen challenge on airway responsiveness to cysteinyl leukotriene D(4) and methacholine in mild asthma. | 2002 | Thorax | pmid:12096198 |
Shirasaki H et al. | Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. | 2002 | Clin. Exp. Allergy | pmid:12100046 |
Thodeti CK et al. | Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells. | 2002 | Biochem. J. | pmid:12071848 |
Bäck M | Functional characteristics of cysteinyl-leukotriene receptor subtypes. | 2002 | Life Sci. | pmid:12072150 |
Terada T et al. | Effect of oral antigen administration on nasal blockage in experimental allergic rhinitis in guinea pigs. | 2002 | Inflamm. Res. | pmid:12058959 |
Nag S et al. | Interleukin-2-induced increased airway responsiveness and lung Th2 cytokine expression occur after antigen challenge through the leukotriene pathway. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12045130 |
Sheller J et al. | The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428688 |
Karaman O et al. | The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. | 2001 Mar-Apr | Allergol Immunopathol (Madr) | pmid:11420028 |
Martin V et al. | Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. | 2001 | Biochem. Pharmacol. | pmid:11705452 |
Aoki M et al. | Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11504812 |
Bäck M et al. | An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. | 2001 | Br. J. Pharmacol. | pmid:11487525 |
Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
Oliveira SH et al. | SCF-induced airway hyperreactivity is dependent on leukotriene production. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11350804 |
Gauvreau GM et al. | Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11704602 |
Shi ZZ et al. | Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. | 2001 | Mol. Cell. Biol. | pmid:11463821 |
Möhle R et al. | Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors. | 2001 | Ann. N. Y. Acad. Sci. | pmid:11458515 |
Mizutani N et al. | Markedly increased nasal blockage by intranasal leukotriene D4 in an experimental allergic rhinitis model: contribution of dilated mucosal blood vessels. | 2001 | Jpn. J. Pharmacol. | pmid:11459119 |
Kawagishi Y et al. | [Clinical significance of measurement of urinary leukotriene E4 in asthmatic patients without attack]. | 2001 | Arerugi | pmid:11761885 |
Kawada N et al. | The effect of leukotriene D(4) inhalation on the antigen-induced airway hyperresponsiveness and inflammation in 5-lipoxygenase gene-deficient mice. | 2001 | Int. Arch. Allergy Immunol. | pmid:11815738 |
Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
Hui Y et al. | The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. | 2001 | J. Biol. Chem. | pmid:11591709 |
Nishimura H et al. | Acute effects of prostaglandin D2 to induce airflow obstruction and airway microvascular leakage in guinea pigs: role of thromboxane A2 receptors. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11519790 |