Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Cyrus CB et al. | Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. | 1998 | Otolaryngol Head Neck Surg | pmid:9560097 |
Zwaagstra ME et al. | Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. | 1998 | J. Med. Chem. | pmid:9554876 |
Habib GM et al. | Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9560193 |
Massoumi R and Sjölander A | The inflammatory mediator leukotriene D4 triggers a rapid reorganisation of the actin cytoskeleton in human intestinal epithelial cells. | 1998 | Eur. J. Cell Biol. | pmid:9716265 |
Shirasaki H et al. | The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. | 1998 | Rhinology | pmid:9695159 |
Nagase T and Ludwig MS | Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. | 1998 | Can. J. Physiol. Pharmacol. | pmid:9635157 |
Przylipiak A et al. | Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. | 1998 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:9550202 |
Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
Jonsson EW | Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. | 1998 | Acta Physiol Scand Suppl | pmid:9597121 |
Cho JS et al. | The effect of leukotriene D4 on the patency of nasal passage in the guinea pig. | 1998 Nov-Dec | Am J Rhinol | pmid:9883299 |
Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
Yamashita T and Kokubun S | Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588484 |
Lärfars G et al. | Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. | 1999 | Blood | pmid:9949184 |
Habib GM and Lieberman MW | Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. | 1999 | Adv. Exp. Med. Biol. | pmid:10667344 |
Capra V et al. | Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. | 1999 | Adv. Exp. Med. Biol. | pmid:10667347 |
Lankisch TO et al. | High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. | 1999 | Eur. J. Cell Biol. | pmid:10535305 |
Sarau HM et al. | Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | 1999 | Mol. Pharmacol. | pmid:10462554 |
Lynch KR et al. | Characterization of the human cysteinyl leukotriene CysLT1 receptor. | 1999 | Nature | pmid:10391245 |
Busse WW et al. | Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease. | 1999 | Clin. Exp. Allergy | pmid:10421833 |
Han HJ et al. | Leukotriene D4 inhibits Na+ uptake through cAMP and PLC pathways in primary cultured renal proximal tubular cells. | 1999 | Kidney Blood Press. Res. | pmid:10394108 |
Hoffmann EK | Leukotriene D4 (LTD4) activates charybdotoxin-sensitive and -insensitive K+ channels in ehrlich ascites tumor cells. | 1999 | Pflugers Arch. | pmid:10398854 |
Mulder A et al. | Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10228127 |
Pitt CM and Nally JE | Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? | 1999 | Pulm Pharmacol Ther | pmid:10208831 |
Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
Sermasi E et al. | Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience. | 1999 | Brain Res. Dev. Brain Res. | pmid:10064875 |
Olszewski MA et al. | Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. | 1999 | Am. J. Physiol. | pmid:10070118 |
White IJ et al. | A continuous fluorometric assay for leukotriene D4 hydrolase. | 1999 | Anal. Biochem. | pmid:10075814 |
Takami M and Tsukada W | Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents. | 1999 | Eur. J. Pharmacol. | pmid:10082207 |
Yang XX et al. | The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. | 1999 | Pulm Pharmacol Ther | pmid:10545287 |
Olszewski MA et al. | Pre- and postjunctional effects of inflammatory mediators in horse airways. | 1999 | Am. J. Physiol. | pmid:10444527 |
Takizawa T et al. | Effects of a new antiallergic agent, VUF-K-8788, on experimental asthmatic reactions in guinea pigs. | 1999 | Pharmacology | pmid:10450067 |
Yang XX et al. | Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. | 1999 | J. Appl. Physiol. | pmid:9887125 |
Arakida Y et al. | In vivo pharmacologic profile of YM158, a new dual antagonist for leukotriene D4 and thromboxane A2 receptors. | 2000 | Jpn. J. Pharmacol. | pmid:10887942 |
McMahon B et al. | Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. | 2000 | J. Biol. Chem. | pmid:10869343 |
Turner DJ et al. | Bradykinin-induced airway constriction in guinea-pigs: role of leukotriene D(4). | 2000 | Pulm Pharmacol Ther | pmid:10930357 |
Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
Ballart B et al. | Synthesis and pharmacological evaluation of new 4-2-(7-heterocyclemethoxynaftalen-2-ylmethoxy)ethylbenzoic acids as LTD(4)-antagonists. | 2000 | Eur J Med Chem | pmid:10858604 |
Hougaard C et al. | K+ currents activated by leukotriene D4 or osmotic swelling in Ehrlich ascites tumour cells. | 2000 | Pflugers Arch. | pmid:10898529 |
Blain JF and Sirois P | Involvement of LTD(4)in allergic pulmonary inflammation in mice: modulation by cysLT(1)antagonist MK-571. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913229 |
Laberge S et al. | Antigen-induced airway inflammation and hyper-responsiveness does not enhance airway responses to a subsequent antigen challenge in rats. | 2000 | Respir Med | pmid:10714478 |
Thodeti CK et al. | Leukotriene D(4) triggers an association between gbetagamma subunits and phospholipase C-gamma1 in intestinal epithelial cells. | 2000 | J. Biol. Chem. | pmid:10734140 |
Underwood DC et al. | SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10734180 |
Kivity S et al. | Eosinophil influx into the airways in patients with exercise-induced asthma. | 2000 | Respir Med | pmid:11192956 |
Ohd JF et al. | Leukotrienes induce cell-survival signaling in intestinal epithelial cells. | 2000 | Gastroenterology | pmid:11040187 |
Robbiani DF et al. | The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. | 2000 | Cell | pmid:11114332 |
Hasday JD et al. | Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10764316 |
Hisamatsu K and Nakajima M | Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. | 2000 | Life Sci. | pmid:11105993 |
Bäck M et al. | Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936497 |
Kodani M et al. | Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes. | 2000 | Immunopharmacology | pmid:10996024 |
Bäck M et al. | Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936498 |