Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Zhou Y et al. | Circulating LTD4 in patients with hepatocellular carcinoma. | 2011 | Tumour Biol. | pmid:20820981 |
Hayashi S et al. | Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. | 2010 | Bioorg. Med. Chem. | pmid:20875743 |
McGovern T et al. | LTDâ‚„ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20889674 |
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Rehni AK and Singh TG | Modulation of leukotriene D4 attenuates the development of seizures in mice. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21641195 |
Mizutani N et al. | Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis. | 2012 | Phytother Res | pmid:21698671 |
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Ni NC et al. | A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. | 2011 | J. Pharmacol. Exp. Ther. | pmid:21903747 |
Drost AC et al. | The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia. | 2012 | Leuk. Lymphoma | pmid:21936770 |
Matsumoto H et al. | Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells. | 2012 | Cytokine | pmid:22078634 |
Ahmed T et al. | Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence. | 2012 | Respir. Res. | pmid:22269021 |
Muccitelli RM et al. | Cysteinyl leukotriene receptor assays. | 2001 | Curr Protoc Pharmacol | pmid:22293965 |
Dannull J et al. | Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. | 2012 | Blood | pmid:22323449 |
Rehn M and Diener M | Cysteinyl leukotrienes mediate the response of submucosal ganglia from rat colon to bradykinin. | 2012 | Eur. J. Pharmacol. | pmid:22366210 |
Parmentier CN et al. | Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1. | 2012 | J. Allergy Clin. Immunol. | pmid:22391114 |
Guan W et al. | Leukotriene D4 bronchial provocation test: methodology and diagnostic value. | 2012 | Curr Med Res Opin | pmid:22435894 |
Dahlén B et al. | Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22457014 |
Forsell PK et al. | Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. | 2012 | Lipids | pmid:22684912 |
Huang XQ et al. | Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1. | 2012 | J Neuroinflammation | pmid:22734808 |
Pelclová D et al. | Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. | 2012 | Ind Health | pmid:22785421 |
Provost V et al. | Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. | 2012 | PLoS ONE | pmid:22952702 |
Tang SS et al. | Leukotriene D4 induces cognitive impairment through enhancement of CysLT₠R-mediated amyloid-β generation in mice. | 2013 | Neuropharmacology | pmid:22982445 |
Guan W et al. | Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes. | 2013 | J. Allergy Clin. Immunol. | pmid:23040886 |
Celik D et al. | Cysteinyl leukotrienes in exhaled breath condensate of smoking asthmatics. | 2013 | Clin. Chem. Lab. Med. | pmid:23045385 |
Wan D et al. | The effects of montelukast on eosinophilic gastroenteritis in a mouse model. | 2013 | Immunopharmacol Immunotoxicol | pmid:23240855 |
Wang XY et al. | Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. | 2013 | Neurochem. Int. | pmid:23318673 |
Germain AR et al. | Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23403082 |
Jørgensen ST et al. | Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization. | 2013 | Cell. Physiol. Biochem. | pmid:23485744 |
Kanaoka Y et al. | Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. | 2013 | J. Biol. Chem. | pmid:23504326 |
Kumasawa F et al. | Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23517395 |
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RodrÃguez-Lagunas MJ et al. | 5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23583294 |
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Doherty TA et al. | Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. | 2013 | J. Allergy Clin. Immunol. | pmid:23688412 |