Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lärfars G et al. | Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. | 1999 | Blood | pmid:9949184 |
Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
Ohbayashi H et al. | Neutral endopeptidase 3.4.24.11 inhibition potentiates the inhibitory effects of type-C natriuretic peptide on leukotriene D4-induced airway changes. | 1998 | Clin. Exp. Pharmacol. Physiol. | pmid:9887994 |
Yang XX et al. | Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. | 1999 | J. Appl. Physiol. | pmid:9887125 |
Cho JS et al. | The effect of leukotriene D4 on the patency of nasal passage in the guinea pig. | 1998 Nov-Dec | Am J Rhinol | pmid:9883299 |
Chambers RJ et al. | Development of new chromanol antagonists of leukotriene D4. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873435 |
von Sprecher A et al. | Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871521 |
Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
Underwood DC et al. | Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9864284 |
Lane SJ | Leukotriene antagonism in asthma and rhinitis. | 1998 | Respir Med | pmid:9850362 |
Kawashima Y et al. | Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose. | 1998 | Pharm. Res. | pmid:9833999 |
Fujimura M et al. | A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs. | 1998 | Br. J. Pharmacol. | pmid:9831931 |
Kjellström S et al. | On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. | 1998 | J Chromatogr A | pmid:9818423 |
Arakida Y et al. | In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9808690 |
Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
pmid:9797038 | ||||
Grönroos E et al. | Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane. | 1998 | Cell Calcium | pmid:9793684 |
Tsang F et al. | Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. | 1998 | Br. J. Pharmacol. | pmid:9776345 |
Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
Kim N et al. | Leukotriene D4-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. | 1998 | Gastroenterology | pmid:9753495 |
Nagayama S et al. | Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078. | 1998 | Cancer Lett. | pmid:9751271 |
Geirsson A et al. | Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. | 1998 | J. Cell. Physiol. | pmid:9731750 |
Panettieri RA et al. | Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9730873 |
Massoumi R and Sjölander A | The inflammatory mediator leukotriene D4 triggers a rapid reorganisation of the actin cytoskeleton in human intestinal epithelial cells. | 1998 | Eur. J. Cell Biol. | pmid:9716265 |
Marcelle R | Leukotrienes antagonist-inhibitor and the bronchial response to inhaled antigen in actively sensitized guinea-pigs. | 1998 | Arch. Physiol. Biochem. | pmid:9711356 |
Shirasaki H et al. | The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs. | 1998 | Rhinology | pmid:9695159 |
Smith LJ et al. | A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9690572 |
Liu YC et al. | Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. | 1998 | Br. J. Pharmacol. | pmid:9647482 |
Traianedes K et al. | 5-Lipoxygenase metabolites inhibit bone formation in vitro. | 1998 | Endocrinology | pmid:9645691 |
Allen S et al. | Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. | 1998 | Circulation | pmid:9641692 |
Nagase T and Ludwig MS | Antigen-induced responses in lung parenchymal strips during sinusoidal oscillation. | 1998 | Can. J. Physiol. Pharmacol. | pmid:9635157 |
Aharony D | Pharmacology of leukotriene receptor antagonists | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620942 |
Kohno S | [Role of peptide-leukotrienes in bronchial asthma]. | 1998 | Nippon Yakurigaku Zasshi | pmid:9618707 |
Ohbayashi H et al. | Compared effects of natriuretic peptides on ovalbumin-induced asthmatic model. | 1998 | Eur. J. Pharmacol. | pmid:9617752 |
Sato E et al. | Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. | 1998 | Am. J. Physiol. | pmid:9609736 |
Sparatore A and Sparatore F | Synthesis and preliminary pharmacological investigation of some 2-[4-(dialkylaminoalkoxy)phenyl]benzotriazoles and their N-oxides. | 1998 | Farmaco | pmid:9604317 |
Jonsson EW | Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. | 1998 | Acta Physiol Scand Suppl | pmid:9597121 |
Dahlén B et al. | Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9563738 |
von Sprecher A et al. | CGP57698: a structurally simple, highly potent peptido-leukotriene (pLT) antagonist of the quinoline type. | 1997 | Adv. Exp. Med. Biol. | pmid:9561127 |
Ohd JF et al. | Leukotriene D4-induced signalling events in human epithelial cells: G alpha i3 activation and translocation. | 1997 | Adv. Exp. Med. Biol. | pmid:9561113 |
Habib GM et al. | Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9560193 |
Cyrus CB et al. | Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. | 1998 | Otolaryngol Head Neck Surg | pmid:9560097 |
Zwaagstra ME et al. | Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. | 1998 | J. Med. Chem. | pmid:9554876 |
Przylipiak A et al. | Influence of leukotrienes on in vitro growth of human mammary carcinoma cell line MCF-7. | 1998 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:9550202 |
Capra V et al. | Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. | 1998 | Mol. Pharmacol. | pmid:9547367 |
Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
Capra V et al. | Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. | 1998 | Br. J. Pharmacol. | pmid:9504401 |
Basavappa S et al. | Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells. | 1998 | J. Neurophysiol. | pmid:9497423 |
Yamaya M et al. | Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. | 1998 | Respir Physiol | pmid:9496476 |