Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
Yamashita T and Kokubun S | Nonselective cationic currents activated by acetylcholine in swine tracheal smooth muscle cells. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588484 |
Lärfars G et al. | Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. | 1999 | Blood | pmid:9949184 |
Habib GM and Lieberman MW | Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. | 1999 | Adv. Exp. Med. Biol. | pmid:10667344 |
Capra V et al. | Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. | 1999 | Adv. Exp. Med. Biol. | pmid:10667347 |
Lankisch TO et al. | High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. | 1999 | Eur. J. Cell Biol. | pmid:10535305 |
Sarau HM et al. | Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | 1999 | Mol. Pharmacol. | pmid:10462554 |
Lynch KR et al. | Characterization of the human cysteinyl leukotriene CysLT1 receptor. | 1999 | Nature | pmid:10391245 |
Busse WW et al. | Leukotriene pathway inhibitors in asthma and chronic obstructive pulmonary disease. | 1999 | Clin. Exp. Allergy | pmid:10421833 |
Han HJ et al. | Leukotriene D4 inhibits Na+ uptake through cAMP and PLC pathways in primary cultured renal proximal tubular cells. | 1999 | Kidney Blood Press. Res. | pmid:10394108 |
Hoffmann EK | Leukotriene D4 (LTD4) activates charybdotoxin-sensitive and -insensitive K+ channels in ehrlich ascites tumor cells. | 1999 | Pflugers Arch. | pmid:10398854 |
Mulder A et al. | Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10228127 |
Pitt CM and Nally JE | Angiotensin II-mediated potentiation of endothelin-1-evoked bronchial contractions: a role for leukotrienes? | 1999 | Pulm Pharmacol Ther | pmid:10208831 |
Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
Sermasi E et al. | Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience. | 1999 | Brain Res. Dev. Brain Res. | pmid:10064875 |
Olszewski MA et al. | Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. | 1999 | Am. J. Physiol. | pmid:10070118 |
Yang XX et al. | The beta(2)-agonist salbutamol inhibits bronchoconstriction and leukotriene D(4) synthesis after dry gas hyperpnea in the guinea-pig. | 1999 | Pulm Pharmacol Ther | pmid:10545287 |
Olszewski MA et al. | Pre- and postjunctional effects of inflammatory mediators in horse airways. | 1999 | Am. J. Physiol. | pmid:10444527 |
Takizawa T et al. | Effects of a new antiallergic agent, VUF-K-8788, on experimental asthmatic reactions in guinea pigs. | 1999 | Pharmacology | pmid:10450067 |
Yang XX et al. | Strain dependence of the airway response to dry-gas hyperpnea challenge in the rat. | 1999 | J. Appl. Physiol. | pmid:9887125 |