Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kondeti V et al. | Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. | 2016 | J. Allergy Clin. Immunol. | pmid:26255103 |
Woszczek G et al. | Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. | 2008 | J. Allergy Clin. Immunol. | pmid:18028998 |
Espinosa K et al. | CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. | 2003 | J. Allergy Clin. Immunol. | pmid:12743568 |
Crimi N et al. | Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin A-induced bronchoconstriction. | 2003 | J. Allergy Clin. Immunol. | pmid:12704366 |
Doherty TA et al. | Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. | 2013 | J. Allergy Clin. Immunol. | pmid:23688412 |
Guan W et al. | Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes. | 2013 | J. Allergy Clin. Immunol. | pmid:23040886 |
Thivierge M et al. | Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. | 2006 | J. Allergy Clin. Immunol. | pmid:16675346 |
Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
Lee TH et al. | Leukotriene E4: perspective on the forgotten mediator. | 2009 | J. Allergy Clin. Immunol. | pmid:19482346 |
Austen KF et al. | The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. | 2009 | J. Allergy Clin. Immunol. | pmid:19647860 |
Asakura T et al. | Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta. | 2004 | J. Allergy Clin. Immunol. | pmid:15316508 |
Rael E | Unraveling the complexity of leukotriene and prostaglandin inflammatory signaling. | 2016 | J. Allergy Clin. Immunol. | pmid:26518091 |
Gyllfors P et al. | Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. | 2006 | J. Allergy Clin. Immunol. | pmid:16815141 |
Braccioni F et al. | The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. | 2002 | J. Allergy Clin. Immunol. | pmid:12110827 |
Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
Bochner BS and Busse WW | Allergy and asthma. | 2005 | J. Allergy Clin. Immunol. | pmid:15867851 |
Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
Lamoureux J et al. | Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes. | 2006 | J. Allergy Clin. Immunol. | pmid:16630953 |
Nagata M et al. | Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor. | 2002 | J. Allergy Clin. Immunol. | pmid:11941318 |