LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang XY et al. | Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. | 2013 | Neurochem. Int. | pmid:23318673 |
| Celik D et al. | Cysteinyl leukotrienes in exhaled breath condensate of smoking asthmatics. | 2013 | Clin. Chem. Lab. Med. | pmid:23045385 |
| Guan W et al. | Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes. | 2013 | J. Allergy Clin. Immunol. | pmid:23040886 |
| RodrÃguez-Lagunas MJ et al. | 5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23583294 |
| Kumasawa F et al. | Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23517395 |
| Ramos-RamÃrez P et al. | Antigen-induced airway hyperresponsiveness in absence of broncho-obstruction in sensitized guinea pigs. | 2013 | Exp. Lung Res. | pmid:23527782 |
| Kouyama S et al. | A contraction assay system using primary cultured mouse bronchial smooth muscle cells. | 2013 | Int. Arch. Allergy Immunol. | pmid:23711859 |
| Guan WJ et al. | Impulse oscillometry for leukotriene D4 inhalation challenge in asthma. | 2013 | Respir Care | pmid:23716710 |
| Kanaoka Y et al. | Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. | 2013 | J. Biol. Chem. | pmid:23504326 |
| Cummings HE et al. | Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. | 2013 | J. Immunol. | pmid:24244016 |