Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nishida T et al. | Effects of leukotriene D4 on myocardial blood flow and high energy phosphate concentration in anesthetized dogs. | 1994 | Jpn. Circ. J. | pmid:7967000 |
Hoheisel U and Mense S | Leukotriene D4 depresses the mechanosensitivity of group III and IV muscle receptors in the rat. | 1994 | Neuroreport | pmid:8025261 |
Hirata F et al. | IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7945342 |
Ichinose M et al. | Antigen-induced airway responses are inhibited by a potassium channel opener. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:7519521 |
Javed NH et al. | Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs. | 1994 | Agents Actions | pmid:7521569 |
Tudhope SR et al. | BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. | 1994 | Eur. J. Pharmacol. | pmid:7698171 |
Callaghan DH et al. | Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection. | 1994 | Pulm Pharmacol | pmid:8003850 |
Dandurand RJ et al. | In vitro allergic bronchoconstriction in the brown Norway rat. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8004305 |
Underwood DC et al. | Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8035322 |
Kano M | Calcium-induced long-lasting potentiation of GABAergic currents in cerebellar Purkinje cells. | 1994 | Jpn. J. Physiol. | pmid:7752516 |