Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Welch MJ et al. | Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. | 1994 | Ann Allergy | pmid:8154635 |
Hendeles L and Marshik PL | Zileuton: a new therapy for asthma or just the first of a new class of drugs. | 1996 Jul-Aug | Ann Pharmacother | pmid:8826576 |
Kim SH et al. | Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells. | 2009 | Ann. Allergy Asthma Immunol. | pmid:19852204 |
Smith LJ et al. | A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9690572 |
Shirasaki H et al. | Agonist- and T(H)2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes. | 2007 | Ann. Allergy Asthma Immunol. | pmid:17941281 |
Saito K et al. | Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin. | 2004 | Ann. Allergy Asthma Immunol. | pmid:15609771 |
Simons FE et al. | Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast. | 2001 | Ann. Allergy Asthma Immunol. | pmid:11206237 |
Sjölander A and Grönroos E | Leukotriene D4-induced signal transduction. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825836 |
Krell RD et al. | Preclinical exploration of the potential antiinflammatory properties of the peptide leukotriene antagonist ICI 204,219 (Accolate). | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825851 |
Möhle R et al. | Transendothelial migration of hematopoietic progenitor cells. Role of chemotactic factors. | 2001 | Ann. N. Y. Acad. Sci. | pmid:11458515 |
Mayatepek E et al. | A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. | 2005 | Ann. Neurol. | pmid:16315285 |
Konno A et al. | Role of substance P in the vascular response of nasal mucosa in nasal allergy. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8712637 |
Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
Abe M et al. | A novel method for preserving human lungs using a super-cooling system. | 2006 | Ann. Thorac. Surg. | pmid:16928543 |
Hoopes C | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16928544 |
Marcelle R | Leukotrienes antagonist-inhibitor and the bronchial response to inhaled antigen in actively sensitized guinea-pigs. | 1998 | Arch. Physiol. Biochem. | pmid:9711356 |
Kawagishi Y et al. | [Clinical significance of measurement of urinary leukotriene E4 in asthmatic patients without attack]. | 2001 | Arerugi | pmid:11761885 |
Fauler J et al. | Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. | 1994 | Arthritis Rheum. | pmid:8129769 |
Tasaka K et al. | Effect of loratadine on immediate and delayed type hypersensitivity reactions. | 1995 | Arzneimittelforschung | pmid:8573225 |