Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid:27666014 | ||||
Lukic A et al. | Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. | 2016 | J. Lipid Res. | pmid:27436590 |
Bellamkonda K et al. | The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model. | 2016 | BMC Cancer | pmid:27388564 |
Park SY et al. | Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer. | 2016 | Oncotarget | pmid:26824987 |
Rael E | Unraveling the complexity of leukotriene and prostaglandin inflammatory signaling. | 2016 | J. Allergy Clin. Immunol. | pmid:26518091 |
Sekioka T et al. | Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction. | 2015 | Allergol Int | pmid:26433531 |
Noguchi T et al. | Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation. | 2015 | Allergol Int | pmid:26344080 |
Kondeti V et al. | Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. | 2016 | J. Allergy Clin. Immunol. | pmid:26255103 |
pmid:26115646 | ||||
Al-Husseini A et al. | Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension. | 2015 | PLoS ONE | pmid:25785937 |
pmid:25707327 | ||||
pmid:25704617 | ||||
pmid:25512344 | ||||
Xiao J et al. | Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. | 2015 | Toxicol. Sci. | pmid:25432964 |
Bukiya AN et al. | Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. | 2014 | J. Biol. Chem. | pmid:25371198 |
Arthur S and Sundaram U | Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25231108 |
Minobe E et al. | A new phosphorylation site in cardiac L-type Ca2+ channels (Cav1.2) responsible for its cAMP-mediated modulation. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25209265 |
Al-Azzam N et al. | Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions. | 2015 | J. Cell. Physiol. | pmid:25161061 |
Bellamkonda K et al. | The impact of inflammatory lipid mediators on colon cancer-initiating cells. | 2015 | Mol. Carcinog. | pmid:25154976 |
pmid:25103494 | ||||
pmid:25090924 | ||||
Inada T et al. | Intravenous anesthetic propofol suppresses prostaglandin E2 and cysteinyl leukotriene production and reduces edema formation in arachidonic acid-induced ear inflammation. | J Immunotoxicol | pmid:25046027 | |
Linares Segovia B et al. | Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. | 2014 | BMC Pulm Med | pmid:25000942 |
pmid:24958577 | ||||
Cosentino S et al. | Expression of dual nucleotides/cysteinyl-leukotrienes receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction. | 2014 | J. Cell. Mol. Med. | pmid:24909956 |
pmid:24735655 | ||||
Mills K et al. | Vitamin E, γ-tocopherol, diminishes ex vivo basophil response to dust mite allergen. | 2014 | Allergy | pmid:24697338 |
pmid:24506412 | ||||
Kawakami Y et al. | Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. | 2014 | Biochim. Biophys. Acta | pmid:24361619 |
Cummings HE et al. | Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. | 2013 | J. Immunol. | pmid:24244016 |
Salim T et al. | The inflammatory mediator leukotriene D₄ induces subcellular β-catenin translocation and migration of colon cancer cells. | 2014 | Exp. Cell Res. | pmid:24211746 |
Yu SY et al. | Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro. | 2014 | Acta Pharmacol. Sin. | pmid:24141567 |
Sharkey LC et al. | Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23993975 |
Capra V and Rovati GE | Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. | 2014 | Pulm Pharmacol Ther | pmid:23806820 |
Zhang Z et al. | [Leukotriene D4 activates BV2 microglia in vitro]. | 2013 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:23801612 |
Kang KH et al. | Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. | 2013 | Neuropharmacology | pmid:23800665 |
O'Brien E et al. | Bisphenol A at concentrations relevant to human exposure enhances histamine and cysteinyl leukotriene release from bone marrow-derived mast cells. | 2014 Jan-Mar | J Immunotoxicol | pmid:23782309 |
Guan WJ et al. | Impulse oscillometry for leukotriene D4 inhalation challenge in asthma. | 2013 | Respir Care | pmid:23716710 |
Kouyama S et al. | A contraction assay system using primary cultured mouse bronchial smooth muscle cells. | 2013 | Int. Arch. Allergy Immunol. | pmid:23711859 |
Matsuse H et al. | Differential airway inflammatory responses in asthma exacerbations induced by respiratory syncytial virus and influenza virus a. | 2013 | Int. Arch. Allergy Immunol. | pmid:23689185 |
Doherty TA et al. | Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. | 2013 | J. Allergy Clin. Immunol. | pmid:23688412 |
Syslová K et al. | Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23644905 |
RodrÃguez-Lagunas MJ et al. | 5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23583294 |
Ramos-RamÃrez P et al. | Antigen-induced airway hyperresponsiveness in absence of broncho-obstruction in sensitized guinea pigs. | 2013 | Exp. Lung Res. | pmid:23527782 |
Kumasawa F et al. | Mitogen-activated protein kinase (MAPK) regulates leukotriene D4-induced HB-EGF and ADAM12 expression in human airway smooth muscle cells. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23517395 |
Kanaoka Y et al. | Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. | 2013 | J. Biol. Chem. | pmid:23504326 |
Jørgensen ST et al. | Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization. | 2013 | Cell. Physiol. Biochem. | pmid:23485744 |
Germain AR et al. | Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23403082 |
Wang XY et al. | Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. | 2013 | Neurochem. Int. | pmid:23318673 |
Wan D et al. | The effects of montelukast on eosinophilic gastroenteritis in a mouse model. | 2013 | Immunopharmacol Immunotoxicol | pmid:23240855 |