LTD4

Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.

Cross Reference

Introduction

To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTD4?

LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTD4

MeSH term MeSH ID Detail
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Inflammation D007249 119 associated lipids
Inflammatory Bowel Diseases D015212 9 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Gastritis D005756 27 associated lipids
Rhinitis D012220 10 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Leukemia D007938 74 associated lipids
Glomerulonephritis D005921 35 associated lipids
Brain Edema D001929 20 associated lipids
Seizures D012640 87 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Enteritis D004751 8 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Carotid Stenosis D016893 15 associated lipids
Influenza, Human D007251 11 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Endotoxemia D019446 27 associated lipids
Respirovirus Infections D010253 3 associated lipids
Neuralgia D009437 28 associated lipids
Sneezing D012912 6 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Nasal Obstruction D015508 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Asbestosis D001195 8 associated lipids
Aspergillosis, Allergic Bronchopulmonary D001229 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTD4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTD4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTD4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTD4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTD4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTD4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTD4

Download all related citations
Per page 10 20 50 100 | Total 640
Authors Title Published Journal PubMed Link
Ohshima N et al. A functional study on CysLT(1) receptors in human eosinophils. 2002 Int. Arch. Allergy Immunol. pmid:12373000
Uemura M et al. Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. 2002 J. Gastroenterol. pmid:12424566
Kurogi Y Mesangial cell proliferation inhibitors for the treatment of proliferative glomerular disease. 2003 Med Res Rev pmid:12424751
Sheller J et al. The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. 2002 Prostaglandins Other Lipid Mediat. pmid:12428688
Shahbazian A et al. Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. 2002 Br. J. Pharmacol. pmid:12429577
Evans JF Cysteinyl leukotriene receptors. 2002 Prostaglandins Other Lipid Mediat. pmid:12432945
Walch L et al. Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. 2002 Br. J. Pharmacol. pmid:12466244
Wikström K et al. The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage. 2003 Biochem. J. pmid:12482325
Nagase T et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12505870
Liu P et al. Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12531730
Peters SP Leukotriene receptor antagonists in asthma therapy. 2003 J. Allergy Clin. Immunol. pmid:12532087
Mazzetti L et al. The ACh-induced contraction in rat aortas is mediated by the Cys Lt1 receptor via intracellular calcium mobilization in smooth muscle cells. 2003 Br. J. Pharmacol. pmid:12598425
Mizutani N [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. 2003 Yakugaku Zasshi pmid:12607939
Smyth TP et al. A substrate variant as a high-affinity, reversible inhibitor: insight from the X-ray structure of cilastatin bound to membrane dipeptidase. 2003 Bioorg. Med. Chem. pmid:12614884
Hattori T et al. Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. 2003 Eur. J. Pharmacol. pmid:12620501
Klegeris A and McGeer PL Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP. 2003 J. Leukoc. Biol. pmid:12629151
Stelmach I et al. The effect of inhaled heparin on airway responsiveness to histamine and leukotriene D4. 2003 Jan-Feb Allergy Asthma Proc pmid:12635579
Vargaftig BB and Singer M Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12654629
Thodeti CK and Sjölander A Leukotriene D4-induced calcium signaling in human intestinal epithelial cells. 2002 Adv. Exp. Med. Biol. pmid:12664584
Chibana K et al. Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. 2003 J. Immunol. pmid:12682264