Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tang SS et al. | Leukotriene D4 induces cognitive impairment through enhancement of CysLT₠R-mediated amyloid-β generation in mice. | 2013 | Neuropharmacology | pmid:22982445 |
Provost V et al. | Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells. | 2012 | PLoS ONE | pmid:22952702 |
Pelclová D et al. | Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. | 2012 | Ind Health | pmid:22785421 |
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Parmentier CN et al. | Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1. | 2012 | J. Allergy Clin. Immunol. | pmid:22391114 |
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Muccitelli RM et al. | Cysteinyl leukotriene receptor assays. | 2001 | Curr Protoc Pharmacol | pmid:22293965 |
Ahmed T et al. | Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence. | 2012 | Respir. Res. | pmid:22269021 |
Matsumoto H et al. | Interleukin-13 enhanced Ca2+ oscillations in airway smooth muscle cells. | 2012 | Cytokine | pmid:22078634 |
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Haneda Y et al. | Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages. | 2011 | Cytokine | pmid:21482134 |
Huang SC | Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. | 2011 | Life Sci. | pmid:21396378 |
Dartt DA et al. | Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | 2011 | J. Immunol. | pmid:21357260 |
Xu L et al. | Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings. | 2010 | Pharmazie | pmid:21105577 |
Brochu-Bourque A et al. | Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor. | 2011 | J. Pharmacol. Exp. Ther. | pmid:20966037 |
McGovern T et al. | LTDâ‚„ induces HB-EGF-dependent CXCL8 release through EGFR activation in human bronchial epithelial cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20889674 |
Hayashi S et al. | Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. | 2010 | Bioorg. Med. Chem. | pmid:20875743 |
Zhou Y et al. | Circulating LTD4 in patients with hepatocellular carcinoma. | 2011 | Tumour Biol. | pmid:20820981 |
Sakai H et al. | Augmented venous responsiveness to leukotriene D(4) in nasal septal mucosae of repeatedly antigen-challenged rats. | 2010 | Eur. J. Pharmacol. | pmid:20638382 |
Kim MH et al. | Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways. | 2010 | J. Cell. Biochem. | pmid:20589831 |
Li R et al. | [Analysis of the nasopharyngeal aspirates in children with different severities of bronchiolitis]. | 2010 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:20497653 |
Lieber G et al. | Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat. | 2010 | Pharmacology | pmid:20453555 |
Wunder F et al. | Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. | 2010 | Br. J. Pharmacol. | pmid:20423349 |
Julius P et al. | sCD14 in bronchoalveolar lavage 18, 42 and 162 hours after segmental allergen provocation. | 2010 | Scand. J. Immunol. | pmid:20384875 |
Zhou G et al. | Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. | 2010 | Cardiology | pmid:20234134 |
Schäper C et al. | Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. | 2009 | J Investig Allergol Clin Immunol | pmid:20128420 |
Woszczek G et al. | Concentration-dependent noncysteinyl leukotriene type 1 receptor-mediated inhibitory activity of leukotriene receptor antagonists. | 2010 | J. Immunol. | pmid:20083671 |
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Finkensieper A et al. | The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. | 2010 | Cardiovasc. Res. | pmid:19965960 |
Farias S et al. | Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. | 2009 | J. Neurotrauma | pmid:19886806 |
Kim SH et al. | Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells. | 2009 | Ann. Allergy Asthma Immunol. | pmid:19852204 |
Thivierge M et al. | Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins. | 2009 | J. Immunol. | pmid:19846883 |
Lee SJ et al. | 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19837106 |
Mezhybovska M et al. | Beta-catenin is involved in alterations in mitochondrial activity in non-transformed intestinal epithelial and colon cancer cells. | 2009 | Br. J. Cancer | pmid:19826421 |
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Meliton AY et al. | Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes. | 2010 | Eur. Respir. J. | pmid:19679609 |