| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| McMahon B et al. | Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. | 2002 | FASEB J. | pmid:12223454 |
| Thodeti CK and Sjölander A | Leukotriene D4-induced calcium signaling in human intestinal epithelial cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664584 |
| Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |
| Tokuyama K et al. | Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. | 2002 | Pharmacology | pmid:11893899 |
| Lee KH et al. | Increased expression of endothelial cell adhesion molecules due to mediator release from human foreskin mast cells stimulated by autoantibodies in chronic urticaria sera. | 2002 | J. Invest. Dermatol. | pmid:11918713 |
| Karaman O et al. | The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. | 2001 Mar-Apr | Allergol Immunopathol (Madr) | pmid:11420028 |
| Aoki M et al. | Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11259541 |
| Campos MG et al. | Galphimia glauca organic fraction antagonizes LTD(4)-induced contraction in guinea pig airways. | 2001 | J Ethnopharmacol | pmid:11137344 |
| Thodeti CK et al. | The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells. | 2001 | Exp. Cell Res. | pmid:11139333 |
| Venugopal CS et al. | Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pasture-associated obstructive pulmonary disease. | 2001 | Am. J. Vet. Res. | pmid:11212036 |
| Hele DJ et al. | Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats. | 2001 | Br. J. Pharmacol. | pmid:11159698 |
| Mehta KA et al. | Release performance of a poorly soluble drug from a novel, Eudragit-based multi-unit erosion matrix. | 2001 | Int J Pharm | pmid:11165089 |
| Ro JY et al. | The inhibitory mechanism of rebamipide on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions. | 2001 | Pharmacology | pmid:11598424 |
| Thivierge M et al. | IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages. | 2001 | J. Immunol. | pmid:11509632 |
| Bouchelouche K et al. | Calcium signaling in cultured human detrusor smooth muscle cells from patients with interstitial cystitis. | 2001 | Urology | pmid:11378073 |
| Bouchelouche K et al. | Cysteinyl-leukotriene D(4) receptors in smooth muscle cells. | 2001 | Urology | pmid:11378074 |
| Nabe T et al. | Comparison of cedar pollen-induced allergic rhinitis in passively and actively sensitized guinea pigs. | 2001 | Jpn. J. Pharmacol. | pmid:11388645 |
| Ruck LM et al. | Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. | 2001 | Life Sci. | pmid:11432448 |
| Simons FE et al. | Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast. | 2001 | Ann. Allergy Asthma Immunol. | pmid:11206237 |
| Accomazzo MR et al. | Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208655 |