| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
LTD4
Ltd4 is a lipid of Fatty Acyls (FA) class. Ltd4 is associated with abnormalities such as Inflammatory Bowel Diseases, Inflammatory disorder, Asthma, Pneumonia and Allergic asthma. The involved functions are known as inhibitors, Signal Transduction, Cell Survival, antagonists and Phosphorylation. Ltd4 often locates in Membrane, Tissue membrane, Protoplasm, Cytoplasmic matrix and membrane fraction. The associated genes with LTD4 are ALOX5 gene, UMOD gene, P4HTM gene, RAF1 gene and Homologous Gene. The related lipids are Lipopolysaccharides.
Cross Reference
Introduction
To understand associated biological information of LTD4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTD4?
LTD4 is suspected in Asthma, Inflammatory Bowel Diseases, Inflammatory disorder, Pneumonia, Allergic asthma, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTD4
PubChem Associated disorders and diseases
What pathways are associated with LTD4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTD4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTD4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTD4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTD4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTD4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTD4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTD4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ishikawa J et al. | Involvement of endogenous tachykinins in LTD4-induced airway responses. | 1996 | Eur. Respir. J. | pmid:8730008 |
| Meliton AY et al. | Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes. | 2010 | Eur. Respir. J. | pmid:19679609 |
| Diamant Z et al. | Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. | 1994 | Eur. Respir. J. | pmid:8013602 |
| Dahlén B et al. | The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics. | 1994 | Eur. Respir. J. | pmid:8162986 |
| Casas A et al. | Leukotriene D4-induced hypoxaemia in asthma is mediated by the cys-leukotriene1 receptor. | 2005 | Eur. Respir. J. | pmid:16135725 |
| Salim T et al. | The inflammatory mediator leukotriene D₄ induces subcellular β-catenin translocation and migration of colon cancer cells. | 2014 | Exp. Cell Res. | pmid:24211746 |
| Massoumi R et al. | Leukotriene D4-induced adhesion of Caco-2 cells is mediated by prostaglandin E2 and upregulation of alpha2beta1-integrin. | 2003 | Exp. Cell Res. | pmid:14499635 |
| Thodeti CK et al. | The epsilon isoform of protein kinase C is involved in regulation of the LTD(4)-induced calcium signal in human intestinal epithelial cells. | 2001 | Exp. Cell Res. | pmid:11139333 |
| Nielsen CK et al. | Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation. | 2005 | Exp. Cell Res. | pmid:15541723 |
| Ramos-RamÃrez P et al. | Antigen-induced airway hyperresponsiveness in absence of broncho-obstruction in sensitized guinea pigs. | 2013 | Exp. Lung Res. | pmid:23527782 |
| Ochsner M | The action of the peptidoleukotriene LTD4 on intracellular calcium in rat mesangial cells. | 1996 | Experientia | pmid:8841513 |
| Sparatore A and Sparatore F | Preparation and pharmacological activities of 10-homolupinanoyl-2-R-phenothiazines. | 1994 | Farmaco | pmid:7910463 |
| Sparatore A and Sparatore F | Synthesis and preliminary pharmacological investigation of some 2-[4-(dialkylaminoalkoxy)phenyl]benzotriazoles and their N-oxides. | 1998 | Farmaco | pmid:9604317 |
| McMahon B et al. | Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. | 2002 | FASEB J. | pmid:12223454 |
| Claesson HE et al. | Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma. | 2008 | FEBS J. | pmid:18647347 |
| Tanaka T et al. | Protective effect of peptide leukotriene antagonist on renal failure induced by a tourniquet in rabbits. | 1995 | Forensic Sci. Int. | pmid:7875619 |
| Kelley M et al. | Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. | 1994 | Fundam Appl Toxicol | pmid:7982537 |
| Bonnefoi MS et al. | Subchronic toxicity studies with the leukotriene D4 antagonist RG 12525. | 1995 | Fundam Appl Toxicol | pmid:8566477 |
| Martin CA et al. | In vitro pharmacological effects of S 12370 (2-[4-benzhydryloxypiperidinoethyl]isoxindole; an antibronchoconstrictor agent) in normal and sensitized tissue. | 1996 | Fundam Clin Pharmacol | pmid:8902549 |
| Honda I et al. | Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction. | 1997 | Fundam Clin Pharmacol | pmid:9243258 |